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Postdoc Positions

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Molecular Medicine


Principal Investigator Brunhilde Felding
Department: Molecular Medicine
Location: La Jolla, CA
Maildrop: MEM-150
Email application materials to: brunie@scripps.edu
URL: http://www.scripps.edu/felding-habermann/
Research Description:

A post doctoral position is immediately available for a highly motivated scientist to study tumor cell responses to new treatments targeting mechanisms of cancer progression. We have used unbiased approaches including genomic, metabolomics, and functional analyses of highly aggressive human cancer cells in vitro and in vivo, and identified NAD+ metabolism and mitochondrial activities as critically involved in determining the cancer cell phenotype. The research associate will study new clinically relevant treatments and combination therapies aimed at normalizing the cancer cell phenotype and/or selectively inducing senescence to target aggressive cancer cells and critically enhance treatment responsiveness, even in cancer cells that are refractory to conventional therapy. The individual will work closely with members of our team and collaborators toward translationally relevant discovery.

This project is integrated with other studies in the Felding lab, all aimed at identifying new targeted and selectively effective therapies against cancer progression. The collaborative environment at TSRI and the discovery-based nature of this project will foster multidisciplinary thinking and creativity. This opportunity provides the potential for advancing expertise in cutting-edge cancer biology and translational science to uniquely enhance the career of a self-driven and brilliant post doctoral researcher.


Interested candidates are asked to send their CV, a statement of research interests and career objectives, along with a list of 3 references to Brunie Felding (brunie@scripps.edu).

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
The candidate must have a strong background in molecular and cancer cell biology, genetic engineering, and cell signaling. The person should have experience in generating mutant gene constructs, experimentally modifying gene expression and inducing ectopic protein expression in mammalian cells. Knowledge and expertise in cellular metabolism, genomics analyses, cell fate determination, and protein biochemistry are highly desired.

The researcher is expected to work independently and follow the current literature to reliably plan, execute and document experiments and creatively strive to find answers in a complex field, being inspired and immersing themselves in our interdisciplinary research environment.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Laura Bohn
Department: Molecular Medicine
Location: Jupiter, FL
Email application materials to: LBohn@scripps.edu
URL: https://www.scripps.edu/research/faculty/bohn
Research Description:

The Scripps Research Institute, Florida- An early-stage post-doctoral research position is available in the Bohn Laboratory of Scripps Florida in the area of GPCR pharmacology and drug discovery. The ideal candidate has relevant experience in evaluating GPCR signaling transduction pathways, is highly organized and self-motivated and is competent in data analysis. Publications and a PhD in a relevant discipline are required. The Department of Molecular Medicine at Scripps Florida is comprised of researchers with both academic and industry research experience providing a unique training environment for the candidate undecided between an academic and industrial research track.

Position Requirements: Please send a cover letter describing your interests in the laboratory as well as your CV and list of 3 references that can provide letters of recommendation to:
Dr. Laura M. Bohn, Professor of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, FL. via: LBohn@scripps.edu
The Scripps Research Institute, Jupiter, FL (LBohn@scripps.edu). TSRI embraces diversity & recognizes it as being a key to our success. EOE/M/F/V/D
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Paul Robbins
Department: Molecular Medicine
Location: Jupiter, FL
Email application materials to: kmclaugh@scripps.edu
URL: https://www.scripps.edu/florida/research/faculty/robbins
Research Description:

A post-doctoral research position is immediately available in the laboratory of Dr. Paul Robbins in the Department of Molecular Medicine at The Scripps Research Institute (TSRI), Florida. This position is to work on characterizing extracellular vesicles secreted by adult stem cells from young, but not old mice that can extend lifespan and health span in a mouse model of accelerated aging. The postdoctoral fellow will join an exciting research environment in the Department of Molecular Medicine in the new state-of-the-art facilities of the Scripps Florida campus of The Scripps Research Institute. The position offers exceptional training in stem cell biology, extracellular vesicles, drug screening, age-related degenerative diseases, mouse models of aging, signal transduction, cellular senescence and molecular therapeutics.

Position Requirements: Applicants must have a Ph.D. degree, experience in molecular and cellular biology, and interest in working with murine models of age-related disease. Special attention will be given to applicants with significant experience in stem cells, extracellular vesicles, mammalian cell culture, drug screening, metabolism and/or mitochondrial biology. Interested applicants should submit a copy of their CV, including a summary of research experience and interests, along with contact information for 3 references to kmclaugh@scripps.edu
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Vaughn Smider
Department: Molecular Medicine
Division: 3
Location: La Jolla, CA
Maildrop: MEM-150
Email application materials to: vvsmider@scripps.edu
URL: http://www.scripps.edu/smider/
Research Description:

A post-doctoral fellowship is available in Dr. Vaughn Smider’s lab the field of antibody biology and protein engineering. The successful candidate will have experience in cell culture, PCR, cloning, transfection/transformation and antibody purification, and a demonstrated record of high quality science in peer-reviewed publications. The ability to work within a team and communicate well are essential, and collaborative opportunities with other laboratories are likely. Phage display and bioinformatics skills are desireable as well. A one to two year commitment is envisioned.

We are a small but dynamic group, and are very invested in mentoring individuals so that they can develop both scientifically and professionally. More information on the group is available at: http://www.scripps.edu/smider/

Please send a cover letter and resumes directly to vvsmider@scripps.edu

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Supriya Srinivasan
Department: Molecular Medicine
Division: 3
Location: La Jolla, CA
Maildrop: DNC-202
Email application materials to: supriya@scripps.edu
URL: http://www.scripps.edu/srinivasan/
Research Description:

We are seeking a motivated postdoctoral fellow to work in the area of neural circuits and neuroendocrine biology of metabolism. It is now well-established that body fat is under the control of brain circuits, and can be potently regulated independently of feeding behavior. In the context of living animals, the neuroendocrine signals and physiology of body fat control remain poorly understood. We utilize C. elegans for its powerful molecular genetics and pathway discovery, cell culture systems for biochemical insights and mouse models for physiology. A major focus of our work is to decipher mechanisms underlying the gut-brain axis.
Our research program is uniquely juxtaposed at the intersection of neuroscience and physiology, and offers an exciting new perspective on the biology of metabolic and neuronal control. Our approach integrates several disciplines including molecular genetics, chemical biology, neuroscience, behavior and physiology. The Scripps Research Institute is one of the world’s leading biomedical research institutes, and offers outstanding scientific opportunities for collaborations with laboratories engaged in cutting-edge science and novel technologies.

Position Requirements: Ph.D. in genetics, neuroscience, biochemistry, physiology or related disciplines. The candidate should have a strong background in molecular biology and neuroscience, and a conceptual understanding of molecular genetics, biochemistry or physiology. First-author publications (or manuscripts in press) are a must, along with the interest and capacity to obtain postdoctoral fellowships. Previous experience with C. elegans is not a requirement. The candidate must be driven, possess a sense of scientific curiosity, and enjoy working in a team-oriented and stimulating environment. Please apply with your CV, a brief statement of research interests and the names of 2-3 supervisors and mentors who can be contacted for references.

Please send CV and additional information to aglenn@scripps.edu
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Larry Gerace
Department: Molecular Medicine
Division: 3
Location: La Jolla, CA
Maildrop: IMM-10
Email application materials to: lgerace@scripps.edu
URL: http://www.scripps.edu/gerace/
Research Description:

A postdoctoral position is available in the Gerace laboratory for a highly motivated individual to study the role of nuclear envelope proteins in nuclear organization and functions. This project is a component of the NIH 4D nucleome initiative and involves close collaboration with the Yates laboratory at TSRI. Using proteomics, we have identified a group of novel nuclear envelope proteins with potential roles in signaling, nuclear membrane dynamics and gene regulation. The individual will analyze the functions of these proteins in mesenchymal stem cells and determine their roles in adipocyte and myocyte differentiation. The person also will participate in mapping the interactions of these proteins with nuclear lamina and chromosome components. This project is integrated with other studies in the Gerace lab involving animal and cultured cell models that investigate regulation of signaling in the cell nucleus and ER. The collaborative environment at TSRI and the discovery-based nature of this project will foster multidisciplinary thinking, and will provide the potential for advancing expertise in cutting-edge cell biology and imaging technologies.

The candidate must have a strong background in the use of cell and molecular biology techniques for analysis of protein function in mammalian cells. The person should be experienced in generation of mutant gene constructs, implementation of gene knockdown and knockout, and expression of ectopic proteins in mammalian cultured cells by lentiviral and other transduction methods. Experience with immunofluorescence microscopy and light microscope imaging is beneficial.

Interested candidates are asked to send their CV, a statement of research interests and career objectives, and a list of 3 references to Larry Gerace lgerace@scripps.edu.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Sergio Catz
Department: Molecular Medicine
Division: 3
Location: La Jolla, CA
Maildrop: MEM-280
Email application materials to: scatz@scripps.edu
URL: http://www.scripps.edu/catz/
Research Description:

A Postdoctoral research position is available immediately in the laboratory of Dr. Sergio D. Catz at the Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla. We are looking for a highly motivated scientist to contribute to our research projects designed to study the crosstalk between vesicular trafficking mechanisms and autophagy in the context of lysosomal storage disorders. The selected scientist will join our efforts to study the cellular and molecular mechanisms involved in the regulation of vesicular transport in proximal tubule cells, focusing on the roles of small Rab GTPases and their effectors in lysosomal exocytosis, endosomal maturation, lysosomal overload, ER stress and autophagy. The candidate will use a combination of molecular, cellular, genetic and drug-discovery approaches to study lysosomal function and chaperone-mediated autophagy using cells from genetically modified mouse models and human cellular models of lysosomal disease.

To apply please send your resume and cover letter to Dr. Sergio Catz at: scatz@scripps.edu

Position Requirements: A Ph.D. in cellular biology and or molecular biology is required.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Peng Wu
Department: Molecular Medicine
Division: 3
Location: La Jolla, CA
Maildrop: MB-208
Email application materials to: pengwu@scripps.edu
URL: http://www.scripps.edu/pwu/index.php/research/
Research Description:

A NIH-funded postdoctoral position is available for highly motivated candidates to study glycosylation in cancer immunology in the laboratory of Prof. Peng Wu, Department of Chemical Physiology, The Scripps Research Institute, La Jolla CA.

Interested candidates should send an application packet, including all of the following as a single PDF file by email to Dr. Peng Wu (pengwu@scripps.edu):
1. Cover letter indicating current and future research interests;
2. Expected starting date;
3. Curriculum vitae;
4. Brief summary of previous research experience (2-3 pages);
5. Names and contact information for 3 references.

Links:

http://www.scripps.edu/pwu/

Position Requirements: Successful candidates will have a recent Ph.D. in chemical biology, glycobiology, cell biology or immunology. Training in multi-color flow cytometry, fluorescent imaging, T-cell or cancer immunology is a plus.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Ted Kamenecka
Department: Molecular Medicine
Location: Jupiter, FL
Email application materials to: KOBrien@scripps.edu
URL: https://www.scripps.edu/research/faculty/kamenecka
Research Description:

Postdoctoral positions in Medicinal Chemistry are available in the Kamenecka group in The Department of Molecular Therapeutics at the Scripps Research Institute, Florida campus (for more information please see: https://www.scripps.edu/research/faculty/kamenecka). Successful candidates will have a proven track record of publishing in high impact journals and extensive experience in organic synthesis and/or medicinal chemistry, and can work successfully as a member of a team. These full-time lab positions are available starting August 2016.

Position Requirements: Extensive Ph.D. graduate work in multi-step organic synthesis is required, with good laboratory skills and familiarity with modern synthetic techniques and instrumentation (HPLC-MS, HPLC, NMR, chromatography). Strong candidates may also have knowledge and experience in heterocyclic and medicinal chemistry and/or structure-based drug design. Excellent communication skills and interpersonal skills necessary to thrive in a fast-paced team-oriented environment are also required.

Please send CV, research summary, and 3 references to: Kate O’Brien, Scripps Florida, 130 Scripps Way #2A1, Jupiter, FL 33458; or preferably by e-mail: KOBrien@scripps.edu (please include “medicinal chemistry postdoctoral recruiting” in the subject line).

EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Richard Milner
Department: Molecular Medicine
Division: 3
Location: La Jolla, CA
Maildrop: MEM-132
Email application materials to: rmilner@scripps.edu
Research Description:

A postdoctoral position is available in the Milner lab at the Scripps Research Institute (TSRI) in La Jolla, California, to work on vascular remodeling and blood-brain barrier (BBB) integrity in inflammatory demyelinating disease. The research will focus on the roles of specific extracellular matrix (ECM) receptors (integrins) to either promote vascular remodeling or stabilize BBB integrity. This study will employ the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis and will include the use of several endothelial-specific integrin-deficient transgenic mouse strains to define the roles of these integrins in regulating BBB integrity, vascular remodeling, vascular inflammation and activation of endothelial signaling pathways.

Position Requirements: The ideal candidates should have experience with the mouse EAE model and with standard genotyping and immuno-histochemical techniques. The position can begin as early as this May. Interested candidates should send a CV and a list of three potential referees to Dr. Richard Milner, rmilner@scripps.edu
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator William Balch
Department: Molecular Medicine
Division: 3
Location: La Jolla, CA
Maildrop: MB-6
Email application materials to: webalch@scripps.edu
URL: http://www.scripps.edu/balch/
Research Description:

Position open for an early stage fellow to study the cell and systems biology of human rare disease impacting liver, lung and/or brain function. Interest in membrane biology, protein folding and trafficking through the secretory pathway, and the impact of protein misfolding on human healthspan is of high interest.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Knowledge of mammalian tissue culture, biochemical, and cell and molecular techniques essential. Experience with handling of mice considered an asset.

Interested candidates should submit their CV and a list of at least 3 professional references to webalch@scripps.edu or ellab@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Claudio Joazeiro
Department: Molecular Medicine
Division: 3
Location: La Jolla, CA
Maildrop: CB-163
Email application materials to: joazeiro@scripps.edu
URL: http://www.scripps.edu/joazeiro/
Research Description:

Research in the lab investigates the function of E3 ubiquitin ligases in biology and disease (Deshaies & Joazeiro, 2009. Annu Rev Biochem. 78:399-434). The position available is to elucidate the mechanism of action of the Listerin E3 in a novel pathway of ribosome-associated protein quality control, and/or how defects in Listerin function cause neurodegeneration. We had previously reported on a new mouse model of ALS/motor neuron disease caused by mutation of Listerin/Ltn1, whose function was unknown at the time (Chu et al. 2009. PNAS 106:2097-103). Listerin is conserved in eukaryotes, so we utilized S. cerevisiae to elucidate its function and mechanism of action, and found that Listerin is associated with ribosomes and mediates quality control of aberrant nascent proteins (Bengtson & Joazeiro 2010. Nature 467:470-3). Our lab is now undertaking different approaches to continue studying Listerin, including biochemistry, yeast genetics, structural biology, mammalian tissue culture, and gene-disease association studies using ALS patient samples. We are also well positioned to uncover novel molecular mechanisms underlying neurodegeneration by applying the discoveries we make with these approaches to studies on the Listerin mutant mouse model. There are opportunities for studies along any of the above research lines, depending on the background and interests of the applicant.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: A Ph.D. in Biology or in other disciplines of relevance to the project is required. The candidate should have strong conceptual and experimental background in related areas. He/she should be proactive and productive, and have track record of successful project completion.

Interested applicants, please send a paragraph on current and future research interests, and the names and contact information of three references to joazeiro@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Matthew Gill
Department: Molecular Medicine
Location: Jupiter, FL
Email application materials to: mgill@scripps.edu
URL: https://www.scripps.edu
Research Description:

A post-doctoral position is available in the laboratory of Dr Matthew Gill in the Department of Metabolism & Aging at The Scripps Research Institute, Scripps Florida. Work in the lab is focused on characterizing signaling pathways in the nematode C. elegans that are involved in development and lifespan determination. This is being achieved by using an interdisciplinary approach combining genetic, genomic, biochemical and analytical chemistry approaches. The broader significance of this research is to further define the role of these signaling pathways in the etiology of aging and age-related disease and identify new targets for therapeutic intervention.

Position Requirements: Requirements: The position requires a PhD in a related scientific discipline with experience and publications demonstrating expertise in any of the following areas: genetics, molecular biology, protein expression & purification, lipid analysis or cell culture. Experience working with C. elegans and / or a background in aging research would be preferred but is not required.
To be considered, please send a cover letter describing your research interests, your CV, copies of representative publications, and a list of three individuals that can serve as references to Dr. Matthew Gill, mgill@scripps.edu.

For more information, visit www.scripps.edu. TSRI embraces diversity & recognizes it as being a key to our success. EOE/M/F/V/D
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Sandra Encalada
Department: Molecular Medicine
Division: 3
Location: La Jolla, CA
Maildrop: MEM-215
Email application materials to: encalada@scripps.edu
URL: http://www.scripps.edu/encalada/
Research Description:

A postdoctoral position is available in the Encalada Laboratory at The Scripps Research Institute in La Jolla, California, USA, in the areas of neurodegeneration, aging, and intracellular transport. Our lab is interested in characterizing the mechanisms of regulation of molecular motor-driven transport in neurons and the role that defective transport plays in neurodegeneration and aging, with an emphasis on prion, Alzheimer’s and other aggregation-associated degenerative diseases. We use a combination of cell biology, genetics, biochemistry, and high-resolution quantitative microscopy in mammalian neurons and in C. elegans to address these research areas, and possible projects include characterization of model organism models of neurodegenerative diseases.

Position Requirements: You are about to complete your PhD or have completed your PhD within the last year in cell biology, genetics, neurobiology, molecular biology, biophysics, or related field.
Preferred candidates are highly motivated, independent, with outstanding written and oral communication skills, and ideally with peer-reviewed publications. Plus research experience with C. elegans and/or cell culture, and with light microscopy is preferred but not required.

Interested candidates please send a CV with a list of publications, a brief statement of your previous research expertise, future interests, and the contact information of three references to Sandra Encalada at encalada@scripps.edu. For more information also please consult our website at http://www.scripps.edu/encalada/encalada/HOME.html
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.