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Postdoc Positions

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Molecular Medicine


Principal Investigator Edward Roberts
Department: Molecular Medicine
Location: La Jolla, CA
Email application materials to: eroberts@scripps.edu
Research Description:

We are seeking a highly talented and motivated individual with a strong background in synthetic organic chemistry to join our medicinal chemistry program as a postdoctoral associate in the Department of Molecular Medicine at The Scripps Research Institute. We are seeking to develop and optimize S1PR3-selective ligands with improved potency, selectivity, and pharmacokinetic properties. Current S1P receptor ligands will be optimized for potency and functional selectivity for S1PR3 versus other S1P receptor family members; S1P1, S1P2, S1P4, and S1P5. Physicochemical properties of S1PR3 selective compounds including microsome stability, solubility, total polar surface area and pharmacokinetics properties will be optimized for in vivo use.

The selected candidate will participate in the molecular design, synthesis, analysis of SAR and DMPK data. Specifically, the primary responsibility of the candidate will be in the lab designing and synthesizing novel chemical compounds to optimize potency, selectivity, pharmacokinetics and in vivo efficacy. As a member of a dynamic, multi-disciplinary team, the selected candidate will collaborate closely with a broad group of scientists within The Scripps Research Institute and contract research organizations (CROs)

Interested applicants should send their curriculum vitae and contact information to Edward Roberts directly at: eroberts@scripps.edu

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Applicants must have PhD in synthetic organic chemistry and be a first author on at least 2-3 publications. This position requires extensive experience in designing synthetic routes for new classes of compounds, solving challenging synthetic problems. Applicants need an expertise in using HPLC, NMR and MS for organic chemistry applications.


This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Michalina Janiszewska
Department: Molecular Medicine
Division: 3
Location: Jupiter, FL
Maildrop: 2A2
Email application materials to: mjaniszewska@scripps.edu
URL: https://www.scripps.edu/janiszewska/
Research Description:

Research description:
Postdoctoral research positions in the field of cancer biology are available in Dr. Michalina Janiszewska’s laboratory, within the Department of Molecular Medicine. Our goal is to understand how intratumor heterogeneity contributes to cancer progression and treatment resistance in highly aggressive brain tumors. Areas of study related to this position include spatial organization of cancer cell subpopulations within a tumor, stem cell hierarchies, and interactions between cancer cells and microenvironment. Our approach involves the development of new technologies, applicable to human tissues and in vivo and in vitro models.


The ideal candidate has experience in cancer biology research, tumor evolution, genetics or epigenetics, is highly motivated, well-organized and eager to work in a highly collaborative team. Candidates with experience in situ techniques, confocal microscopy or mouse models will be preferred. Skills such as image analysis with ImageJ or MatLab, experience with next-generation sequencing data analysis (R language), are also of interest.




Position Requirements: Ph.D. in cancer biology, molecular or cellular biology or related field is required.
Please send a cover letter with a description of your research interests in the laboratory, as well as your CV and contact information for three mentors who will provide reference letters to mjaniszewska@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Helen Makarenkova
Department: Molecular Medicine
Location: La Jolla, CA
Maildrop: SR-307
Email application materials to: jcanseco@scripps.edu
URL: http://www.scripps.edu/makarenkova/
Research Description:

To study the FGF signaling during lacrimal gland growth, regeneration, and inflammation. We are interested in the possible contribution of FGF signaling to the stem and progenitor cell survival and in the regulation of lacrimal gland regeneration. We are also interested in developing of new therapeutic approaches to treat dry eye conditions. We are looking for a candidate with a prior molecular biology and biochemistry experience, a record of publications, and some proficiency with bioinformatics. Technical approaches used in the lab FACS cell isolation, include cell culture, real time PCR, western blotting, immunohistochemistry, viral expression, reporter gene expression, gene knockout, RNA-seq, single cell RNA-seq and public database mining.

A Postdoctoral Associate is a direct pay individual in a Division 3 status. Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges.

Please send your CV/Resume to Helen Makarenkova at: hmakarenk@scripps.edu

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Proficiency in molecular biology techniques (RNA-seq or ChIP-seq), FACS analysis and/or primary cell cultures is desired.

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Stuart Lipton
Department: Molecular Medicine
Location: La Jolla, CA
Email application materials to: slipton@scripps.edu
URL: https://www.scripps.edu/lipton/index.html
Research Description:

Postdoctoral position in neurodevelopmental and neurodegenerative diseases using hiPSCs and mouse models.

A postdoctoral position is available in the Lipton lab at The Scripps Research Institute (TSRI) to study neurodevelopmental and neurodegenerative diseases using patient-derived human induced pluripotent stem cells (hiPSCs) as well as genetic mouse models. Our goal is to understand how specific gene mutations and posttranslational modifications that mimic the effect of such mutations, such as aberrant protein S-nitrosylation, contribute to synaptic damage. We also develop new drug therapies for these diseases. Ongoing research in the lab uses “disease-in-a-dish” models generated from hiPSCs in 2D cultures and 3D-brain organoids (“mini-brains”). A plethora of techniques are employed including chemical biology, molecular biology, patch-clamp electrophysiology and calcium imaging.
The candidate is expected to be highly motivated, possess an ability to troubleshoot and work well independently and with others. Tissue culture and molecular biology experience is preferred.

Stuart Lipton, MD, PhD is Professor and Co-Director of the new Neuroscience Translational Center at TSRI. The laboratory is in the Departments of Molecular Medicine and Neuroscience, and is located in the Calibr Building for Drug Discovery on North Torrey Pines Road in La Jolla. We provide competitive salary, fringe benefits and scientific support plus a commitment to helping our trainees advance their careers.

Please send your CV/Resume to Dr. Stuart Lipton at: slipton@scripps.edu

Position Requirements: We are looking for individuals who want to study both transgenic/knock out mouse and hiPSC-based models, and who meet the following criteria:

1) Ph.D. in neuroscience, biology, pharmacology, or a related field.
2) A track record of thoughtful scientific inquiry (e.g., first author publication).
3) Experience at the intersection of two or more of the following fields: Cell biology, molecular biology, biochemistry, confocal imaging/quantitative neurohistology, electrophysiology, pharmacology, data analysis.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Larry Gerace
Department: Molecular Medicine
Division: 3
Location: La Jolla, CA
Maildrop: IMM-10
Email application materials to: lgerace@scripps.edu
URL: http://www.scripps.edu/gerace/
Research Description:

A postdoctoral position is available in the Gerace laboratory for a highly motivated individual to study the role of nuclear envelope proteins in nuclear organization and functions. This project is a component of the NIH 4D nucleome initiative and involves close collaboration with the Yates laboratory at TSRI. Using proteomics, we have identified a group of novel nuclear envelope proteins with potential roles in signaling, nuclear membrane dynamics and gene regulation. The individual will analyze the functions of these proteins in mesenchymal stem cells and determine their roles in adipocyte and myocyte differentiation. The person also will participate in mapping the interactions of these proteins with nuclear lamina and chromosome components. This project is integrated with other studies in the Gerace lab involving animal and cultured cell models that investigate regulation of signaling in the cell nucleus and ER. The collaborative environment at TSRI and the discovery-based nature of this project will foster multidisciplinary thinking, and will provide the potential for advancing expertise in cutting-edge cell biology and imaging technologies.

The candidate must have a strong background in the use of cell and molecular biology techniques for analysis of protein function in mammalian cells. The person should be experienced in generation of mutant gene constructs, implementation of gene knockdown and knockout, and expression of ectopic proteins in mammalian cultured cells by lentiviral and other transduction methods. Experience with immunofluorescence microscopy and light microscope imaging is beneficial.

Interested candidates are asked to send their CV, a statement of research interests and career objectives, and a list of 3 references to Larry Gerace lgerace@scripps.edu.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Ted Kamenecka
Department: Molecular Medicine
Location: Jupiter, FL
Email application materials to: KOBrien@scripps.edu
URL: https://www.scripps.edu/research/faculty/kamenecka
Research Description:

Postdoctoral positions in Medicinal Chemistry are available in the Kamenecka group in The Department of Molecular Therapeutics at the Scripps Research Institute, Florida campus (for more information please see: https://www.scripps.edu/research/faculty/kamenecka). Successful candidates will have a proven track record of publishing in high impact journals and extensive experience in organic synthesis and/or medicinal chemistry, and can work successfully as a member of a team. These full-time lab positions are available starting August 2016.

Position Requirements: Extensive Ph.D. graduate work in multi-step organic synthesis is required, with good laboratory skills and familiarity with modern synthetic techniques and instrumentation (HPLC-MS, HPLC, NMR, chromatography). Strong candidates may also have knowledge and experience in heterocyclic and medicinal chemistry and/or structure-based drug design. Excellent communication skills and interpersonal skills necessary to thrive in a fast-paced team-oriented environment are also required.

Please send CV, research summary, and 3 references to: Kate O’Brien, Scripps Florida, 130 Scripps Way #2A1, Jupiter, FL 33458; or preferably by e-mail: KOBrien@scripps.edu (please include “medicinal chemistry postdoctoral recruiting” in the subject line).

EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.