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Postdoc Positions

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Immunology and Microbiology


Principal Investigator Travis Young (Calibr)
Department: Immunology and Microbiology
Division: 3
Location: La Jolla, CA
Email application materials to: tyoung@calibr.org
URL: www.calibr.org/careers
Research Description:

This position is with the California Institute for Biomedical Research (Calibr). To learn more about this opportunity and/ or to apply for consideration, please go to: www.calibr.org/careers

Job ID: 155
The California Institute for Biomedical Research (Calibr) is a not-for-profit research institute located in La Jolla, California. Calibr is focused on innovative early-stage translational research in the areas of regenerative medicine, cancer biology, cardiovascular and metabolic disease, immunology and infectious disease.

Position Overview:
This postdoctoral fellow will work as part of a small team of interdisciplinary scientists to translate novel cell and protein therapies for the treatment of cancer into human clinical trials. Specifically, the project will focus on the development of next-generation CAR-T cell strategies for the treatment of cancer. This opportunity is ideal for postdocs who are interested in learning the drug discovery process and who want to make an impact by being part of a small dynamic team of scientists working at the cutting edge of cellular immunotherapy.

Essential Duties and Responsibilities:
• Research, design, and execution of cutting-edge programs in cellular and protein sciences.
• Cell biology including working with primary human immune cells and culturing multiple cell lines including, but not limited to, common tumor cell lines used in immuno-oncology research.
• Execution of experiments involving immune cell profiling, cell processing from xenograft models, cytotoxicity, proliferation, activation, cell viability, and survival assays with a strong focus on flow cytometry.
• Generation of reagents for projects including preparation of lentivirus for the transduction of both established cell lines and primary immune cells.
• Molecular biology experiments including DNA and protein preparation from cells, immunoprecipitation, Western blots, etc. will be.
The California Institute for Biomedical Research (Calibr) is a not-for-profit research institute located in La Jolla, California. Calibr is focused on innovative early-stage translational research in the areas of regenerative medicine, cancer biology, cardiovascular and metabolic disease, immunology and infectious disease.
• Preparation of reports and presentation of results at regular team meetings.

Position Requirements: • A strong background in cell culture is essential.
• Experience and knowledge of the immune system are a required. Experience in T cell biology, tumor immunology, as well as other immune components is preferred.
• Hands-on experience with in vitro assays commonly used in immuno-oncology, and experience preparing reagents for in vivo assays. In vivo experience preferred but not required.
• Experience with multi-color flow cytometry and flow data analysis is required.
• Experience with cell transfection and transduction systems is preferred.
• Experience with molecular biology techniques is preferred.
• Experience using Prism, FlowJo, and Office software is important.

Qualifications:
• Ph.D. in biology, chemical biology, biochemistry or related area. Recent Ph.D. graduate or prior postdoctoral experience are both appropriate.
• Impeccable attention to detail, and excellent ability to perform hands-on experiments, research, design, and organize project designs and maintain detailed documentation.
• Highly motivated, creative, and devoted to project goals.
• Able to collaborate proficiently and communicate effectively with colleagues and management teams.
• Able to contribute in a meaningful way to scientific discourse.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Bryan Briney
Department: Immunology and Microbiology
Location: La Jolla, CA
Email application materials to: briney@scripps.edu
Research Description:

The Briney lab combines cutting-edge sequencing technology and computational immunogenetics approaches to investigate protective immune responses to viral infection. We have active research projects in several areas, including HIV, Lassa and Ebola.

We are looking for a postdoc to lead a new systems immunological project focused on Lassa and Ebola. The goals of this project are identifying functional and genetic features in the adaptive immune response that are associated with desirable clinical outcomes. This position is part of a larger initiative with the recently established Center for Viral Systems Biology (https://cvisb.org).

Primary tasks will include:
• Create and improve techniques for large-scale, cost efficient sequencing of adaptive immune receptor repertoire (TCR and BCR).
• Oversee and directly participate in the isolation and characterization of neutralizing monoclonal antibodies from survivors of Lassa and Ebola infection.
• Work closely with computational biologists to develop novel computational tools for evaluation of antibody repertoire development, maturation and function.
Interested candidates should submit their CV and cover letter to briney@scripps.edu. Please have at least three referees email their references directly to briney@scripps.edu.

Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges.

Position Requirements:
Requirements include:
• Ph.D. in immunology, genetics, molecular biology, or similar is required. A pending doctoral degree may be considered with approval of the Principal Investigator.
• Independent, highly motivated and passionate about harnessing emerging technology to answer fundamental questions about viral immunology.
• Familiarity with common molecular biology techniques (cloning, protein production and purification, assessment of antibody binding/neutralization) is highly desirable.
• Experience performing next-generation sequencing is highly desirable, especially experience with the 10X Genomics Chromium platform or other microfluidics-based single cell analysis platforms.
• Experience handing and manipulating large sequence datasets is highly desirable.
• Programming skills in a scripting language (our lab primarily uses Python) are not required but would be a major plus. Although programming proficiency is not required, the ability to assist in the development of novel computational tools by providing immunological guidance and support to computationally-focused lab members is critical.
• Strong interpersonal skills and the ability to work with and mentor junior scientists and students.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Kristian G. Andersen
Department: Immunology and Microbiology
Location: La Jolla, CA
Email application materials to: jobs@andersen-lab.com
URL: https://andersen-lab.com/
Research Description:

Postdoc position in Computational Biology

The Scripps Research Institute is currently seeking a computational Postdoc for the Andersen Lab working in the Department of Immunology and Microbiology. The successful candidate will join an interdisciplinary team of scientists, biologists, clinicians, and computational scientists to apply computational tools to advance the state of the art in quantitative infectious disease research. We are looking for a dedicated individual who will help us transform medicine with a direct impact on global health.

The Andersen lab is working on diverse projects using computational genomics approaches and high-throughput experiments to study emerging viruses and the outbreaks the cause, including Lassa, Ebola, West Nile, and Zika. We use an integrated approach of fieldwork in West Africa, technology development, and computational biology to investigate these viruses.

We are looking for a computational postdoc to lead new projects developing and using data mining, machine learning and Bayesian phylodynamic approaches to investigate the spread and evolution of emerging viruses, including Lassa and Ebola. This position is part of a larger initiative with the recently established Center for Viral Systems Biology (https://cvisb.org/).

Tasks will include:
• Develop novel data mining strategies and deploy computational tools for the exploration of large biological data sets.
• Perform independent research exploring the utility and applications of next-generation sequencing in a global health setting.
• Develop and implement statistical models; work with wet-lab researchers to translate these models into testable experiments; analyze the data produced from these experiments.
• For interested candidates, fieldwork in Sierra Leone is also a possibility.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges

Interested candidates should submit their CV with links to code repositories(Github/Bitbucket) or online demos and cover letter to jobs@andersen-lab.com. Please have at least three referees email their references directly to references@andersen-lab.com.

Position Requirements: Requirements include:
• Ph.D. in computational biology, computer science, mathematics, physics, or equivalent.
• Programming skills in two or more languages (C++/Java/Python/R/MATLAB).
• Experience with data mining and machine learning is highly desired.
• Data visualization in Python/R/d3js is a plus.
• Experience with HPC preferred.
• Deep knowledge of Bayesian statistics, in particular Bayesian phylogenetics is a big plus.
• Strong interpersonal skills and the ability to work with and mentor junior scientists and students.

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Pietro Sanna, M.D.
Department: Immunology and Microbiology
Division: 3
Location: La Jolla, CA
Maildrop: SP30-2300
Email application materials to: psanna@scripps.edu
Research Description:

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member.

A NIH-funded post-doctoral position is available immediately for a motivated individual to join a dynamic multidisciplinary research team at The Scripps Research Institute to study the effects of alcohol and drugs of abuse with electrophysiological methods.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

A background in bio- physics is preferred.

Send CVs & references to psanna@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Pietro Sanna, M.D.
Department: Immunology and Microbiology
Location: La Jolla, CA
Maildrop: SP30-2300
Email application materials to: psanna@scripps.edu
Research Description:

A post-doctoral position is available immediately for a motivated individual to join a dynamic multidisciplinary research team at The Scripps Research Institute to study the neurobiological bases of drug addiction and dementia with strategies involving anatomy, gene expression by RNA-Seq and cell isolation by FACS and laser microdissection, electrophysiology and pharmacology.

This NIH-funded position offers a competitive pay and benefits package.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

MD, PhD or equivalent. Experience in relevant techniques.

Successful candidates will be creative, highly motivated, and able to work semi-independently.

Send CVs & references to psanna@scripps.edu
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Matthew Pipkin
Department: Immunology and Microbiology
Location: Jupiter, FL
Email application materials to: mpipkin@scripps.edu
URL: http://www.scripps.edu/research/cancer-biology/index.html
Research Description:

The transcriptional circuitry of CTL differentiation:
A postdoctoral position within the Department of Cancer Biology is available to study the genetic, molecular and cellular basis of effector and memory CD8+ cytotoxic T lymphocyte (CTL) differentiation. The candidate will develop new, and use available, strains of reporter and gene deficient mice to examine the regulation of effector and memory CTL development in response to model infections and tumors. These approaches will be combined with custom retroviral shRNA-miR libraries targeting transcriptional regulators, in the context of infectious models in vivo and simplified in vitro differentiation systems, to discover and dissect the transcriptional circuitry of CTL differentiation. To clarify important questions underlying cell-differentiation, the candidate will apply sophisticated genetic and molecular approaches such as chromosome transfer, BAC recombineering and transgenesis, and next generation sequencing of RNA and DNA derived libraries.

Position Requirements: The ideal candidate will have a Ph.D. in immunology, a strong background in genetics, and extensive experience with flow cytometry and or fluorescent microscopy. In addition, experience with mice and a committed desire to learn and apply classical and cutting-edge molecular biology approaches are strongly desired.

Interested applicants should submit a CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: mpipkin@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Matthew Pipkin
Department: Immunology and Microbiology
Location: Jupiter, FL
Email application materials to: mpipkin@scripps.edu
URL: http://www.scripps.edu/research/cancer-biology/index.html
Research Description:

The mechanics of nucleosome positioning:
A postdoctoral position within the Department of Cancer Biology is available to study the transcriptional mechanics underlying effector and memory CD8+ T cell differentiation. The candidate’s goals will be to clarify how transcription factor expression levels combined with their affinities for cognate binding sites in DNA control nucleosome positioning and transcription in vivo. The lab has developed and applied novel approaches that integrate bacterial artificial chromosome (BAC) technology and next generation sequencing to map nucleosomes in vivo at unprecedented resolution. A number of genetic tools and approaches are available in the lab to alter expression of essential CD8 T cell specific transcription factors in vitro and in vivo, such as conditional knockout mice, retrovirally expressed cDNAs and whole-genome retroviral shRNA-miR libraries, to examine at the genome-scale how these factors control nucleosome positions and CTL differentiation.

Position Requirements: The ideal candidate will have a Ph.D. in a biological, chemical, or physical science, a quantitative mindset, and a committed desire to learning and applying classical and cutting-edge molecular and biochemical approaches to address the regulation of chromatin and transcription in the immune system.

Interested applicants should submit a CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: mpipkin@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.