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Postdoc Positions

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Chemistry


Principal Investigator Ram Krishnamurthy
Department: Chemistry
Location: La Jolla, CA
Maildrop: MB-16
Email application materials to: rkrishna@scripps.edu
URL: http://www.scripps.edu/krishnamurthy/
Research Description:

Position for a Post Doctoral Research Associate

Research in the Krishnamurthy lab encompasses a broad spectrum of synthetic chemistry and methodology applied to understanding the chemistry associated with emergence of functional biopolymers and self-assembling structures. This project involves the synthesis and investigation of oligonucleotides, oligopeptides with alternative backbones.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Interested parties should email their CV and a description of their research interests to Prof. Ram Krishnamurthy at rkrishna@scripps.edu and should have three letters of reference forwarded on their behalf. Applicants should, in their cover letter, address what their scientific interests and goals are and how (a) they align with this specific project and (b) this position would help in attaining the long term goals. We are Looking for candidate to start as soon as possible.

Position Requirements: Qualified candidates should have a PhD in organic chemistry and be well grounded in analytical techniques. The applicant should have a synthetic organic chemistry background with a strong emphasis in nucleic acid and oligonucleotide chemistry, coupled with experience in analytical techniques (e.g. HPLC). The applicant should read the following papers (Nat. Chem. 2017 doi:10.1038/nchem.2878 ChemComm. 2015, 51, 5618-5621. and Acc. Chem Res. 2017, 50, 455–459 ) as the projects he/she will be involved in will be along these lines. Only those candidates who evince and express a strong interest in this type of approach and project will be considered.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Peter Schultz
Department: Chemistry
Division: 3
Location: La Jolla, CA
Maildrop: BCC-506
Email application materials to: schultz@scripps.edu
URL: http://www.scripps.edu/schultz/
Research Description:

The research group of Dr. Michael Bollong is seeking a talented Postdoctoral fellow with experience in cell and molecular biology to join a collaborative and interdisciplinary team of scientists focused on small molecule discovery and early stage translational research. Specific research activities include high throughput cell-based screens, molecular and cellular biology, and organismal studies of the effects of novel compounds. Projects involve the elucidation of biologically relevant targets/mechanisms of action and evaluation of the activities of optimized lead molecules in pre-clinical rodent models.

Please note this position will be directly supervised by faculty fellow Dr. Michael Bollong as part of the newly formed TSRI fellows program.

Interested applicants should send their curriculum vitae and contact information for references to Michael Bollong directly at: mbollong@scripps.edu.

Hiring preference given to local applicants.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Kate Carroll
Department: Chemistry
Location: Jupiter, FL
Email application materials to: kcarroll@scripp.edu
URL: http://www.katecarrolllab.com/
Research Description:

Chemistry Postdoctoral position(s) available in the Carroll lab (www.scripps.edu/carroll/) in the Department of Chemistry at The Scripps Research Institute in Jupiter, FL (www.scripps.edu/florida/). The Postdoc will address one of two major themes in the lab: 1. Developing chemical probes to study cellular mechanisms of redox-dependent signaling, and/or 2. Developing small-molecule inhibitors that block sulfur metabolism for preclinical evaluation as antibacterial agents.

Desired Candidate Profile:
• You are holding a PhD in chemistry or related field.
• You have a strong expertise in organic synthesis, with a publication record demonstrating independence in research focus.
• You have the ability to communicate clearly in writing, as well as verbally with a diverse set of collaborators.
• You have a strong team spirit and excellent interpersonal skills.
• You are familiar with cell-based assays and basic molecular biology techniques.
• Applicants with experience in redox chemistry and/or medicinal chemistry are strongly encouraged to apply.

The environment:
Located in Jupiter, Palm Beach County, Scripps Florida provides a rich intellectual environment and cutting-edge facilities for its researchers, who conduct studies at the forefront of basic biomedical science, drug discovery, and technology development.

Position Requirements: Applications will be accepted immediately and candidates will be considered until the position is filled. Completion of a PhD is required by start date.

To be considered, all applicants must submit a cover letter, CV, a one page “Research Statement” describing research experience and how this aligns with the focus of the Carroll group, and the names/phone numbers of three references. A single PDF document should be sent to Prof. Kate Carroll (kcarroll@scripp.edu).

Salary will be commensurate with accomplishment, fit, and experience.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Matthew Disney
Department: Chemistry
Location: Jupiter, FL
Email application materials to: Disney@scripps.edu
URL: http://www.scripps.edu/disney/
Research Description:

Multiple postdoctoral positions in RNA chemical biology are available in the Disney group in the Department of Chemistry at The Scripps Research Institute.

Projects with an emphasis on structural biology include: (i) developing methods to allow for the structural elucidation of RNA-small molecule complexes by using either NMR spectroscopy and computation or X-ray crystallography; (ii) using these structural studies to understand complex formation in a rigorous biophysical manner and lead optimizing compounds; and, (iii) developing methods to study RNA structure in cells by using cell-permeable chemical reagents.

Projects with an emphasis on chemical biology include: (i) developing methods to rapidly expand information on the small molecules that bind RNA and on the RNA motifs that bind small molecules; (ii) using these data to identify new drug targets from only RNA sequence; (iii) using the identified compounds to study RNA biology in cells and in vivo; and (iv) expanding tools available to manipulate RNA in cells.

Representative publications in this area from our group include: studying the RNA repeats that cause genetically defined ALS and dementia (see: Neuron. 2014 Sep 3;83(5):1043-50) and muscular dystrophy (see: Nat. Chem. Biol. 2017 Feb;13(2):188-193); and using sequence-based RNA drug design to develop novel compounds that target non-coding RNAs in highly drug resistant cancers (see: Nat. Chem. Biol. 2014 Apr;10(4):291-7. and Proc. Natl. Acad. Sci. U.S.A. 2016 May 24;113(21):5898-903).

Position Requirements: Successful candidates will have a proven track record of publishing in high impact journals, have experience in nucleic acids, medicinal chemistry, or chemical biology, and can work successfully as a member of a team. An emphasis will be placed on candidates that have a track record of high impact publications. Expertise with RNA-seq data analysis and chemical and structural biology is highly desired.

Interested applicants should send their CV and three letters of reference to disney@scripps.edu. A full description of the group’s research focus is available on the web at http://www.scripps.edu/disney/.


EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.