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Postdoc Positions

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Chemistry


Principal Investigator Edward Roberts
Department: Chemistry
Division: 3
Location: La Jolla, CA
Maildrop: SP-3156
Email application materials to: eroberts@scripps.edu
Research Description:

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Must have extensive work in multi-step organic synthesis; with good laboratory skills and familiarity with modern synthetic techniques and instrumentation (HPLC-MS, HPLC, NMR, chromatography). Strong candidates may also have knowledge and experience in heterocyclic and desire to learn medicinal chemistry and/or structure-based drug design. Excellent communication skills and interpersonal skills necessary to thrive in a fast-paced team-oriented environment are also required. This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Interested parties should email their CV and a description of their research interests to Prof. Edward Roberts at eroberts@scripps.edu along with three letters of reference forwarded on their behalf.
Principal Investigator Chi-Huey Wong
Department: Chemistry
Location: La Jolla, CA
Maildrop: BCC-338
Email application materials to: wong@scripps.edu
URL: http://www.scripps.edu/wong/
Research Description:

Postdoctoral Research Fellowship in the Wong Lab. Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting RNA and design and synthesis of inhibitors to enzymes and receptors are being performed to investigate how small molecules interact with biologically important molecules and in turn, learn more about the function of those molecules.

Position Requirements: Candidates with Ph.D. training in synthetic organic or chemical biology, especially related to glycoscience will be considered. The research project is concerning with development of inhibitors against drug resistant bacterial transglycosidase and influenza surface enzymes/proteins and design of carbohydrate-based vaccines.

Basic knowledge in basic lab procedures & chemical management practices & safety; basic understanding of protein purification and organic synthesis. Also a basic understanding of all biochemical laboratory equipment. Ability to learn new techniques and following instructions.
Principal Investigator Ram Krishnamurthy
Department: Chemistry
Division: 3
Location: La Jolla, CA
Maildrop: MB-16
Email application materials to: rkrishna@scripps.edu
URL: http://www.scripps.edu/krishnamurthy/
Research Description:

Postdoctoral Research Fellowship in the Krishnamurthy Lab. Research in the Krishnamurthy lab encompasses a broad spectrum of synthetic chemistry and methodology applied to understanding the chemistry associated with emergence of RNA. This project involves the synthesis and investigation of oligonucleotides with alternative backbones.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Qualified candidates should have a PhD in organic chemistry and be well grounded in analytical techniques. The applicant should have a synthetic organic chemistry background with a strong emphasis in nucleic acid and oligonucleotide chemistry, coupled with experience in analytical techniques (e.g. HPLC). The applicant should read the following papers (Chem. Eur. J. 2013, 19, 15336-15345. Angew. Chem. Int. Ed. 2013, 52, 5840-5844 Synlett, 2014, 25, 1511-1518) as the projects he/she will be involved in will be along these lines. This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Interested parties should email their CV and a description of their research interests to Prof. Ram Krishnamurthy at rkrishna@scripps.edu and should have three letters of reference forwarded on their behalf. Applicants should, in their cover letter, address what their scientific interests and goals are and how (a) they align with this specific project and (b) this position would help in attaining the long term goals. Looking for candidate to start as soon as possible.
Principal Investigator Matt Disney
Department: Chemistry
Location: Jupiter, FL
Email application materials to: disney@scripps.edu
URL: http://www.scripps.edu/research/faculty/disney
Research Description:

The Disney Lab at Scripps Florida has multiple openings for postdoctoral candidates in the area of rational design of small molecules targeting RNA.

The selected candidate(s) will conduct research in using a combination of approaches to rationally design small molecules targeting RNA (J. Am. Chem. Soc. 2012, 134(10): 4731-4742; ACS Chem. Biol. 2012, in press; and, ACS Chem. Biol. 2012, 7(3): 496-505). Several compounds have been successfully developed to target repeating RNA transcripts that cause diseases such as Myotonic Dystrophy, Huntington’s Disease, et cetera. We are seeking qualified individuals to contribute to future developments in this area including: (i) using a library-versus-library screen to identify and annotate RNA-ligand interactions (described in J. Am. Chem. Soc. 2011, 133(26): 10111-10118 and Angew. Chem. Int. Ed. Engl. 2010, 49(22): 3816-3818); (ii) using computationally approaches (RNA structure modeling) to identify new RNA targets for small molecules from human genomic sequence; and, (iii) further develop lead bioactive compounds in a variety of cellular and animal model systems.

Our laboratory is located at The Scripps Research Institute in Jupiter, Florida. Students interested in careers in academia or in industry are well suited for these positions. Scripps Florida houses high throughput screening, DMPK, and other facilities that uniquely position us for translational research.

Position Requirements: Qualified candidates should have a PhD in a related scientific discipline and an established background in Bioorganic Chemistry or Chemical Biology. Previous experience in RNA folding, RNA biochemistry/biophysics, or nucleic acids biochemistry/biophysics would be helpful, but is not essential.

Interested parties should email their CV and a description of their research interests to Prof. Matt Disney at Disney@scripps.edu and should have three letters of reference forwarded on their behalf. More information about this position and the laboratory can be found at http://www.scripps.edu/disney/.
Principal Investigator Brian Paegel
Department: Chemistry
Location: Jupiter, FL
Email application materials to: briandna@scripps.edu
Research Description:

A postdoctoral fellowship is available in synthetic biology, cell-based screening, and lipid bilayer vesicle assembly in the laboratory of Prof. Brian Paegel at The Scripps Research Institute in Jupiter, FL.

Scripps Florida is a dynamic research environment where scientists with both academic and industry experience work collaboratively, ideal for the postdoctoral fellow who is undecided about future career trajectories.

Position Requirements: To be considered, applicants must have a doctoral degree and published expertise in a
subset of fields including microfluidics, liposome/GUV synthesis and analysis, and membrane protein biochemistry.

If you are interested in joining our highly interdisciplinary team, please submit your cover letter, CV and a sample publication to Dr. Brian Paegel, briandna@scripps.edu.
Principal Investigator Kate Carroll
Department: Chemistry
Location: Jupiter, FL
Email application materials to:
URL: http://www.scripps.edu/research/faculty/carroll
Research Description:

The Carroll lab in the Department of Chemistry at Scripps, Florida currently has NIH-funded postdoctoral positions available in the areas of Cellular and Molecular Biology, Chemical Biology and Synthetic Chemistry.

Position Requirements: Candidates should possess a PhD in a related scientific discipline.

Postdoctoral candidates should send an inquiry with their CV and have three references send letters of recommendation to kcarroll@scrippps.edu.

In the application / cover letter, please address the following: (1) What are your scientific goals and interests, and how might your graduate research background be leveraged to create synergy with the strengths of our laboratory? (2) What, if any, are your plans for obtaining postdoctoral fellowship funding? (3) What are your long-term career plans as of today? Complete applications with published experience in the above focus areas will be given priority.
Principal Investigator Dr. Matt Disney
Department: Chemistry
Location: Jupiter, FL
Email application materials to: JHolmes@scripps.edu
URL: http://www.scripps.edu/research/faculty/disney
Research Description:

A postdoctoral position in RNA chemical biology is available in the Disney group in The Department of Chemistry at The Scripps Research Institute (for more information please see: http://www.scripps.edu/disney/). Successful candidates will have a proven track record of publishing in high impact journals and experience in nucleic acids, medicinal chemistry, or chemical biology and can work successfully as a member of a team. An emphasis will be placed on candidates that have published high impact publications.

The specific focus is on the rational design of small molecules that target RNA for use as both lead therapeutics and chemical probes of function as applied toward diseases that have no known therapeutic or to which there is poor prognosis with current treatments such as inherited neuromuscular diseases such as ALS (see: Neuron. 2014 Sep 3;83(5):1043-50) and Muscular Dystrophy (see: Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10956-9 and ACS Chem Biol. 2013 Oct 18;8(10):2312-21) and highly resistant cancers (see: Nat Chem Biol. 2014 Apr;10(4):291-7).

Position Requirements: Interested applicants should have their CV and three letters of reference sent to JHolmes@scripps.edu