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Principal Investigator Pietro Sanna
Department: Chemistry
Location: La Jolla, CA
Maildrop: SP-2300
Email application materials to: psanna@scripps.edu
Research Description:

A NIH-funded post-doctoral position is available immediately for a motivated individual to join a dynamic multidisciplinary research team at The Scripps Research Institute to study the effects of alcohol and drugs of abuse and neuroHIV with anatomical methods.

Interested applicants should send their curriculum vitae and contact information for references to Pietro Sanna directly at: psanna@scripps.edu

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Peter Schultz
Department: Chemistry
Division: 3
Location: La Jolla, CA
Maildrop: BCC-506
Email application materials to: schultz@scripps.edu
URL: http://www.scripps.edu/schultz/
Research Description:

The research group of Dr. Michael Bollong is seeking a talented Postdoctoral fellow with experience in cell and molecular biology to join a collaborative and interdisciplinary team of scientists focused on small molecule discovery and early stage translational research. Specific research activities include high throughput cell-based screens, molecular and cellular biology, and organismal studies of the effects of novel compounds. Projects involve the elucidation of biologically relevant targets/mechanisms of action and evaluation of the activities of optimized lead molecules in pre-clinical rodent models.

Please note this position will be directly supervised by faculty fellow Dr. Michael Bollong as part of the newly formed TSRI fellows program.

Interested applicants should send their curriculum vitae and contact information for references to Michael Bollong directly at: mbollong@scripps.edu.

Hiring preference given to local applicants.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Matthew Disney
Department: Chemistry
Location: Jupiter, FL
Email application materials to: Disney@scripps.edu
URL: http://www.scripps.edu/disney/
Research Description:

Multiple postdoctoral positions in RNA chemical biology are available in the Disney group in the Department of Chemistry at The Scripps Research Institute. We are committed to each individual’s development to achieve their short term and long term career goals.
Projects with an emphasis on chemical biology center on development of small molecules that target RNA repeat expansions, the causative agent of many neurological and neuromuscular diseases. In particular, the successful candidate will: (i) design high affinity small molecule binders using the structure of the RNA target, our database of RNA-small molecule interactions, and other computational methods; (ii) fully characterize the molecular recognition of the RNA by the small molecule using biophysical methods; (iii) use optimal compounds to study RNA biology in cells and in vivo; and (iv) expand tools available to manipulate RNA in cells. Candidates with demonstrated experience with the following techniques are highly desirable: mammalian cell culture (patient-derived, iPSCs), RNA-seq, splicing isoform analysis by end point RT-PCR and RT-qPCR, RNA-FISH, high throughput screening methods, and conducting experiments in animal models of disease.
Representative publications in this area from our group include: studying the RNA repeats that cause genetically defined ALS and dementia (see: Neuron. 2014 Sep 3;83(5):1043-50); and developing innovative methods to target the RNAs that cause myotonic muscular dystrophy (see: Nat. Chem. Biol. 2017 Feb;13(2):188-193).

Position Requirements: Successful candidates will have a proven track record of publishing in high impact journals, have experience in nucleic acids, medicinal chemistry, or chemical biology, and can work successfully as a member of a team. An emphasis will be placed on candidates that have a track record of high impact publications. Expertise with RNA-seq data analysis and chemical and structural biology is highly desired.

Interested applicants should send their CV and three letters of reference to disney@scripps.edu. A full description of the group’s research focus is available on the web at http://www.scripps.edu/disney/.




EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Olivier George
Department: Neuroscience
Division: 3
Location: La Jolla, CA
Maildrop: SP-2400
Email application materials to: ogeorge@scripps.edu
URL: http://www.scripps.edu/george/
Research Description:

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member.

Experience with behavioral pharmacology expertise, opto/chemogenetics, molecular biology, biochemical techniques is required. The successful candidate should be able to work independently and be willing to collaborate with the lab members and other groups in the Department.

To apply, please send your cover letter and resume to: giordano@scripps.edu

Position Requirements: Candidates must have a PhD in neuroscience, biochemistry, pharmacology or biomedical sciences. A pending doctoral degree may be considered with approval of the Principal Investigator.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Srini Subramaniam
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: ssubrama@scripps.edu
URL: http://www.scripps.edu/subramaniam
Research Description:

Postdoctoral Fellowship¬:
Understanding the Mechanisms of Neurodegenerative disease, using Patient-derived Embryonic Stem Cells.

Postdoctoral position is open in the Department of Neuroscience providing an exciting opportunity to use human embryonic stem cell (hES) models to identify molecular mechanisms of neurodegenerative disease, focusing on Huntington disease. Candidates with a Ph.D. in a relevant research discipline with a strong background in molecular, biochemical, human iPSC/hES culture, in vitro differentiation into neuron or glia are strongly encouraged to apply. A solid record of publication in relevant subject and experience to work both independently and in a group are required for this position.

The goal of the Subramaniam lab is to understand the molecular mechanisms of neurodegenerative disease with special emphasis on tissue-specific mechanisms of neuronal dysfunction. http://www.scripps.edu/subramaniam/

The lab implements, cell culture, biochemical, cell biology, mouse behavior and genomic and proteomic tools to understand the complex regulation of neurodegenerative disease. This position is for three years with a possibility of extension.

Please see below the selected publications for research details:
https://www.ncbi.nlm.nih.gov/pubmed/?term =subramaniam+scripps
Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.
Shahani N, Huang WC, Varnum M, Page DT, Subramaniam S. Neurobiol Aging. 2016 Nov 21;50:134-143.

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.
Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn LM, Scharager-Tapia C, Pascal B, Martinez-Acedo P, Khare K, Subramaniam S. Sci Signal. 2016 Nov 15;9(454):ra111.

Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease.
Swarnkar S, Chen Y, Pryor WM, Shahani N, Page DT, Subramaniam S. Neurobiol Dis. 2015 Oct;82:66-77.

Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade.
Tyagi R, Shahani N, Gorgen L, Ferretti M, Pryor W, Chen PY, Swarnkar S, Worley PF, Karbstein K, Snyder SH, Subramaniam S.
Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00027-3.

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.
Pryor WM, Biagioli M, Shahani N, Swarnkar S, Huang WC, Page DT, MacDonald ME, Subramaniam S.
Sci Signal. 2014 Oct 28;7(349):ra103.


Position Requirements: Interested candidates should submit a single PDF including a cover letter, curriculum vitae and research interests and complete contact information for three professional references to Dr. Srini Subramaniam: ssubrama@scripps.edu TSRI is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Srini Subramaniam
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: ssubrama@scripps.edu
URL: http://www.scripps.edu/subramaniam/index.html
Research Description:

A Post-doctoral position is immediately available in the area of neuronal signaling; focusing on brain function and neurodegenerative disease in Dr. Subramaniam’s laboratory at The Scripps Research Institute, Florida, USA. http://www.scripps.edu/subramaniam/index.html

The Scripps-Florida, Neuroscience department, provides state-of-the-art facilities for research. A successful candidate will experience a high-class intellectual and collaborative atmosphere enriched with excellent faculty and multi-disciplinary research, both within Scripps-Florida and surrounding Max Planck Neuroscience and Florida Atlantic-University Brain Institutes.

Please see below selected publications for the research details:

https://www.ncbi.nlm.nih.gov/pubmed/?term=subramaniam+scripps
Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.
Shahani N, Huang WC, Varnum M, Page DT, Subramaniam S. Neurobiol Aging. 2016 Nov 21;50:134-143.

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.
Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn LM, Scharager-Tapia C, Pascal B, Martinez-Acedo P, Khare K, Subramaniam S. Sci Signal. 2016 Nov 15;9(454):ra111.

Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease.
Swarnkar S, Chen Y, Pryor WM, Shahani N, Page DT, Subramaniam S. Neurobiol Dis. 2015 Oct;82:66-77.

Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade.
Tyagi R, Shahani N, Gorgen L, Ferretti M, Pryor W, Chen PY, Swarnkar S, Worley PF, Karbstein K, Snyder SH, Subramaniam S.
Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00027-3.

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.
Pryor WM, Biagioli M, Shahani N, Swarnkar S, Huang WC, Page DT, MacDonald ME, Subramaniam S.
Sci Signal. 2014 Oct 28;7(349):ra103.

Position Requirements: Position Requirements:

Ph.D. in a related discipline. A candidate with strong interest in dissecting the signaling pathways, using biochemical, genetic, and animal models is encouraged to apply. Aspiring candidate must have a deep knowledge of signaling pathways, previous experience in addressing the mechanisms supported by a publication record. A postdoctoral candidate looking for an opportunity to explore and contribute to neuroscience research is particularly encouraged to apply.

How to apply:

Interested candidates should submit a single PDF including a cover letter, curriculum vitae and research interests and complete contact information for three professional references to Dr. Srini Subramaniam: ssubrama@scripps.edu
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Damon Page
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: paged@scripps.edu
URL: http://www.scripps.edu/page/
Research Description:

A postdoctoral position is available in the Page laboratory in the Department of Neuroscience at The Scripps Research Institute in Jupiter, Florida to investigate mechanisms of neurogenesis & gliogenesis, axon/dendrite growth and synaptic connectivity in the developing mouse cerebral cortex. A major goal of this project is to understand the influence of genetic risk factors for autism and other neurodevelopmental disorders on these processes at the molecular/cellular, circuit and behavioral levels. For information about the laboratory, please visit: www.scripps.edu/page/.

Position Requirements: In addition to a PhD, highly motivated candidates with expertise in developmental biology, genetics, molecular/cell biology, imaging or behavioral neuroscience are encouraged to apply.

Interested candidates should send a cover letter, CV and contact details for three references to Damon Page, Ph.D., email: paged@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Anton Maximov
Department: Neuroscience
Division: 3
Location: La Jolla, CA
Maildrop: DNC-216
Email application materials to: amaximov@scripps.edu
URL: http://www.scripps.edu/maximov/index.html
Research Description:

The Maximov laboratory at the Scripps Research Institute (TSRI) is seeking motivated postdoctoral fellows with prior experience in electrophysiology. Our group uses a multidisciplinary approach to study the molecular mechanisms of synapse formation and structural plasticity in the mammalian forebrain. Successful candidates will be expected to drive independent projects, and will have an opportunity to learn contemporary genetic, imaging and neurobehavioral techniques through collaborations with other lab members.

TSRI is one of the world’s top biomedical research institutes. Our laboratory is a part of the TSRI Dorris Neuroscience Center (DNC) in La Jolla that brings together investigators with interests in neural circuit formation, synaptic plasticity, sensory processing, learning and memory, and aging. New group members will have an excellent opportunity for career development in a highly collaborative environment. To learn more about TSRI, DNC and our lab, please visit:
http://www.scripps.edu
https://www.scripps.edu/research/dorriscenter/
http://www.scripps.edu/maximov/index.html

Position Requirements: • PhD in neuroscience, biophysics or other relevant scientific discipline.
• Strong background in electrophysiological measurements of neuronal excitability and/or synaptic transmission.
• First-author publications (or manuscripts in press)
• Keen interest in leading an exciting research direction, and ability to work in a team-oriented environment.
• While not required, experience with mouse models, viral injections and optogenetic stimulation will be helpful.

Please apply with your CV, a brief statement of research interests, and the names of 2-3 supervisors and mentors who can be contacted for references.

Applications should be sent as single PDF files to: amaximov@scripps.edu
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Srini Subramaniam
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: ssubrama@scripps.edu
URL: http://www.scripps.edu/subramaniam/index.html
Research Description:

A post-doctoral position is available immediately in the Department of Neuroscience, at the Scripps Research Institute-Florida (TSRI-Florida), to study the mechanisms of neurodegeneration. Candidate must hold a PhD degree and have experience in cell signaling, mouse genetics, rodent surgery, stereotaxic injection, anatomy, histology, microscopy and biochemistry.

Position Requirements: Candidate must be highly motivated and have the ability to work in a team. Position is open for two years with potentials of further extension. For the details of the research work, please visit http://www.scripps.edu/subramaniam/index.html
TSRI is an excellent medical research facility that focuses on research and education in the biomedical sciences, making it among the largest private, non-profit biomedical research organizations in the world. Successful candidates will join an exciting scientific community of drug discovery and neuroscience while enjoying natural beauty of Florida. https://www.scripps.edu/florida/
Please send your cover letter and resume with reference details to: Srini Subramaniam: ssubrama@scripps.edu
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Gavin Rumbaugh
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: grumbaug@scripps.edu
URL: http://rumbaugh.florida.scripps.edu/Rumbaugh_Lab/Gavin.html
Research Description:

We are seeking to fill a federally funded postdoctoral position at the Department of Neuroscience, Scripps Research Institute located in Jupiter, Florida. The position will focus on the study of neural network structure and function in mouse models of intellectual disability, autism spectrum disorder and epilepsy.

Position Requirements: Successful candidates will have recently received a Ph.D. degree, have a strong publication record and have prior multi-photon imaging or whole-cell patch clamp experience. Computer programming skills (e.g. MatLAB) are also desired. Please visit the laboratory website at:

http://rumbaugh.florida.scripps.edu/Rumbaugh_Lab/Gavin.html

To apply, please send CV, brief description of research interests and contact information of references to Dr. Gavin Rumbaugh at grumbaug@scripps.edu. The Scripps Research Institute provides an outstanding intellectual environment and access to a wide range of cutting edge technologies.
The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.






EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Ron Davis
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: rdavis@scripps.edu
URL: http://www.scripps.edu/research/faculty/davis
Research Description:

Currently seeking Postdoctoral Research Associates who will work on projects involving small molecule screening against molecular or phenotypic targets for the purpose of identifying new probes and lead compounds for neuroprotection and cognitive enhancement.

Position Requirements: PhD in a relevant scientific discipline and experience with research projects that employ diverse techniques and address questions that range from the molecular to the behavioral is required.

To be considered, submit Curriculum Vitae and complete contact information for at least three professional references as a single PDF file, to rdavis@scripps.edu.

EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Baoji Xu
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: bxu@scripps.edu
URL: http://www.scripps.edu/florida/neuro/bxu.html
Research Description:

We are seeking a motivated postdoctoral research associate who will investigate neural circuits that control feeding behavior and/or energy expenditure. The successful candidate is expected to drive research projects independently by employing genetic, imaging and behavioral approaches.

Position Requirements: • PhD in neuroscience or a related discipline.
• Strong background in molecular biology, behavioral neuroscience, or electrophysiology.
• First-author publications.
• Experience with stereotaxic injection and optogenetics is highly desired.

To be considered, submit curriculum vitae, brief description of research interests and contact information for three references to: bxu@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Kirill Martemyanov
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: kirill@scripps.edu
URL: http://www.scripps.edu/martemyanov
Research Description:

Molecular and Cellular Neurobiology of GPCR Systems

An NIH funded postdoctoral position is available within the Jupiter, FL campus to study molecular, cellular and behavioral aspects of neuronal signaling. We are looking for an energetic colleague with keen interest in science and solid background in the areas of physiology, molecular and cell biology.

The laboratory is interested in delineating mechanisms by which GPCR pathways control reward behavior, vision and provide neural control of the cardiac function. It is expected that the project will contribute to our understanding of the neuropsychiatric diseases, drug addiction and vision loss while focusing on the discovery of the fundamental neurobiological principles. Multidisciplinary approach integrating behavioral characterization of genetic mouse models with live cell imaging, biochemical analysis of signaling reactions and discovery of novel interactions by mass-spectrometry assisted proteomics is envisioned. For details visit the website of the laboratory at http://www.scripps.edu/martemyanov.

Position Requirements: Requirements: PhD in a related scientific discipline and experience with electrophysiological approaches and/or genetic mouse models for investigation of cardiovascular function is required. An energetic colleague with keen interest in science and solid background in the areas of physiology, molecular and cell biology is strongly desired.

To be considered, please send CV, brief description of research interests and contact information of references to Dr. Kirill Martemyanov at kirill@scripps.edu. Both experienced scientists and recent graduates are encouraged to apply. The PI is committed to the career development of trainees.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Ron Davis
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: rdavis@scripps.edu
URL: http://www.scripps.edu/research/faculty/davis
Research Description:

Currently seeking Postdoctoral Research Associates who will work on projects involving the molecular and cellular biology of memory formation in Drosophila and the mouse using genetic, molecular, cellular, anatomical and behavioral approaches. In addition, selected individuals may perform translational research on mood disorders and Alzheimer's disease.

Position Requirements: PhD in a relevant scientific discipline and experience with research projects that employ diverse techniques and address questions that range from the molecular to the behavioral is required.

To be considered, submit Curriculum Vitae and complete contact information for at least three professional references as a single PDF file, to rdavis@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Pejman Mohammadi
Department: Integrative Structural and Computational Biology
Division: 3
Location: La Jolla, CA
Maildrop: SGM-300
Email application materials to: pejman@scripps.edu
Research Description:

Dr. Mohammadi’s lab is looking for computational postdocs to join ongoing efforts in systems genetics and precision medicine projects. Possible projects include, but are not limited to, modeling variation in non-coding genome, identifying regulatory variations that contribute to disease, and combining genetic data with health monitoring sensor data.

Our research is at the interface of Bioinformatics, Statistics, and Computer Science. We develop mathematical frameworks and statistical models to address computational challenges of analyzing variation in genome and its effect on human health. We are participating in basic research, as part of large functional genomics consortia such as the GTEx, and are collaborating closely with medical doctors in clinic to ensure a translational impact.

Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges.

Please send cover letter and resume to:
pejman@scripps.edu

Position Requirements: This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

The position involves developing analysis pipelines for large genomic and biomedical datasets that are theoretically solid and biologically justified. Therefore, candidates holding a PhD in a theoretical field (e.g. Statistics, Computer Science, etc.) with a keen interest in genetics and biomedical research, or those with PhD/MD in biomedical sciences with substantial experience in scientific programming are encouraged to apply for the position. Lastly, experience in analyzing genomic data, NGS data, or probabilistic machine learning is a plus.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Jiang Zhu
Department: Integrative Structural and Computational Biology
Division: 3
Location: La Jolla, CA
Maildrop: IMM-306
Email application materials to: jiang@scripps.edu
Research Description:

An NIH-funded postdoctoral position is available for highly motivated candidates to study the evolution of HIV-1 broadly neutralizing antibodies (bNAbs) in natural infection, and to develop HIV-1 vaccine immunogens for in vivo evaluation, in the laboratory of Prof. Jiang Zhu, Department of Immunology and Microbial Science, Department of Structural and Computational Biology, and Scripps Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery (CHAVI-ID), The Scripps Research Institute, La Jolla, CA.

Potential projects may involve (1) isolating HIV-1 neutralizing antibodies from patient samples or immunized animal samples using single-cell technologies and next-generation sequencing (NGS); (2) determining the lineage patterns of HIV-1 neutralizing antibodies longitudinally during infection and vaccination; (3) computationally designing & optimizing HIV-1 immunogens including epitope-scaffolds, gp140 trimers, and nanoparticles; (4) analyzing immunized animal samples with various assays to evaluate HIV-1-specific B-cell responses and protection.

Please send cover letter and resume to:
jiang@scripps.edu

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Preferred qualifications:
Successful candidates will have a recent Ph.D. in biophysics, biochemistry, structural biology, immunology, and vaccinology. Training in animal immunization or prior experience with antibody and vaccine research will be a plus.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Andrew Su
Department: Integrative Structural and Computational Biology
Division: 3
Location: La Jolla, CA
Maildrop: MEM-216
Email application materials to: asu@scripps.edu
URL: http://sulab.org
Research Description:

The Su Lab is recruiting for multiple postdoctoral associates in bioinformatics and computational biology. These positions will participate in a wide variety of genomics and genetics analyses in close collaboration with world-class experimental researchers at Scripps. Example projects include N-of-1 cancer genomics, osteoarthritis, cystic fibrosis, and microbiomics.

Applicants should have a Ph.D. in bioinformatics or biology, and as well as a good foundation in some form of computer programming and statistics. Past experience working with modern genomics data (next gen sequencing, microarrays, proteomics, etc.) is highly desirable.

More information about the lab's interests can be found at http://sulab.org.

Interested individuals should send their CV, a letter describing research interests, and the names/contact information of 3 references to Dr. Andrew Su at: asu@scripps.edu.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Andrew Su
Department: Integrative Structural and Computational Biology
Division: 3
Location: La Jolla, CA
Maildrop: MEM-216
Email application materials to: asu@scripps.edu
URL: http://sulab.org
Research Description:

The Su Lab is currently recruiting for a postdoctoral associate in bioinformatics software development. This position will participate in the design and development of the Gene Wiki, BioGPS, and/or GeneGames.org. All of these applications developed by our lab embrace the principles of community intelligence and crowdsourcing.

Applicants should have a Ph.D. in bioinformatics or biology, and as well as a good foundation in some form of computer programming and statistics. Past experience working with modern genomics data (next gen sequencing, microarrays, proteomics, etc.) is highly desirable.

More information about the lab's interests can be found at http://sulab.org.

Interested individuals should send their CV, a letter describing research interests, and the names/contact information of 3 references to Dr. Andrew Su at: asu@scripps.edu.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Tina Izard
Department: Integrative Structural and Computational Biology
Location: Jupiter, FL
Email application materials to: cmorrow@scripps.edu
URL: http://www.scripps.edu/izard
Research Description:

Postdoctoral Research Associate positions are immediately available for several projects including structure-function studies of cytoskeletal proteins that control signaling downstream of adherens junctions and focal adhesions. Fellows will join an exciting research environment in new state-of-the-art facilities of the Scripps-Florida campus of The Scripps Research Institute (TSRI), which is renowned in the Structural Biology field. The laboratory is recognized as a world leader in the cytoskeleton field.

The position provides an outstanding training program in protein biochemistry and structure, and also in molecular and cellular biology, in a highly dynamic and team-oriented research program. Successful candidates will work in a cutting-edge research environment that tackles this important new arena in structural and cell biology. The laboratory has outstanding facilities for cell biology, molecular biology, protein expression, purification, and biochemistry, and protein crystallography.

The laboratory collaborates with several other laboratories on campus including exciting collaborative and currently active projects with Drs Pat Griffin, Joe Kissil, Kirill Martenmyanov, Kendall Nettles, Louis Scampavia, Mark Sundrud, Tim Spicer, and Susana Valente. Thus, there are several exciting opportunities for a variety of very interesting projects.

Scripps-Florida provides an incredibly rich scientific environment. Notably, TSRI faculty include an outstanding cadre of senior colleagues, including two Nobel Laureates and twenty Members of The National Academy of Sciences, including several in crystallography and biophysics. In 2008, Scripps-Florida moved into three new, state-of-the-art research buildings and will expand to eventually house 80 faculty-level investigators. Scripps-Florida has a large cast of outstanding Cores that facilitate basic research and drug development. The unique infrastructure at Scripps-Florida includes the application of unique chemical, genomic, proteomic, informatics, and high-throughput screening and engineering tools for the discovery of novel biomolecules.

Scripps-Florida is a member of the South East Regional Collaborative Access Team (SER-CAT) that constructed two beam lines at the Advanced Photon Source (APS) at Argonne National Laboratory. The insertion device and bending magnet beam lines are available for all the synchrotron-related data collection needs for the post-doctoral fellows.

Scripps-Florida provides a HighFlux X-ray diffraction system, specifically a Rigaku MicroMax-007 HF, a second-generation true microfocus rotating anode generator. Scripps-Florida also provides an Osmic VariMax optics system and the Proteros Free Mounting System to control the humidity and to optimize diffraction characteristics, including resolution, mosaicity, and anisotropy, as well as reduced X-ray background. Finally, the X-ray laboratory houses the mar345 Image Plate detector.

Palm Beach County is one of the most sought-after communities in the country and offers residents an incomparable lifestyle in a family-friendly community with public playgrounds and parks and access to world-class shopping and unmatched outdoor recreation. It is one of the safest communities in the United States with virtually no crime. The Atlantic Ocean with its 45 miles of spectacular beaches and signature Coconut Palms provides an exclusive getaway in a warm, sunny climate throughout most of the year. There are a number of exquisite art galleries as well as arts and crafts festivals. This golfer’s paradise is also home of the Professional Golfers Association of America (PGA).

Position Requirements: Applicants with a recently awarded Ph.D. degree and experience in protein crystallography are probably a better fit for this position. Please send CV, brief summary of research experience and interests, and names, addresses, e-mail, and telephone numbers of 3 references to:

Dr. T. Izard (cmorrow@scripps.edu)
Professor
Cell Adhesion Laboratory
Department of Integrative Structural and Computational Biology
The Scripps Research Institute
Jupiter, FL 33458
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Katrin Karbstein
Department: Integrative Structural and Computational Biology
Location: Jupiter, FL
Email application materials to: kkarbst@scripps.edu
URL: http://www.scripps.edu/karbstein/
Research Description:

Postdoctoral Position in Eukaryotic Ribosome Assembly

Research Description: Funded post-doctoral positions are available in Katrin Karbstein’s laboratory (http://www.scripps.edu/karbstein/) to study regulation and quality control mechanisms during ribosome assembly. Combining a variety of in vitro and in vivo methods with modern systems biology approaches, we are exploring degradation pathways, the causes and effects of defective ribosomes, and other fundamental questions in molecular biology. Being located in the Cancer Biology Department, we are also exploring the links between ribosome assembly and cancer. The laboratory is a supportive, fast-paced environment for driven candidates who enjoy a collaborative atmosphere.

Position Requirements: Applicants with published expertise in yeast genetics and biochemistry, or RNA or protein biochemistry, will be given close consideration. Funding is in place for 3+ years. Please send a cover letter discussing your interests in the laboratory as well as your CV and list of 3 individuals as references to kkarbst@scripps.edu.




EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Edward Roberts
Department: Molecular Medicine
Location: La Jolla, CA
Email application materials to: eroberts@scripps.edu
Research Description:

We are seeking a highly talented and motivated individual with a strong background in synthetic organic chemistry to join our medicinal chemistry program as a postdoctoral associate in the Department of Molecular Medicine at The Scripps Research Institute. We are seeking to develop and optimize S1PR3-selective ligands with improved potency, selectivity, and pharmacokinetic properties. Current S1P receptor ligands will be optimized for potency and functional selectivity for S1PR3 versus other S1P receptor family members; S1P1, S1P2, S1P4, and S1P5. Physicochemical properties of S1PR3 selective compounds including microsome stability, solubility, total polar surface area and pharmacokinetics properties will be optimized for in vivo use.

The selected candidate will participate in the molecular design, synthesis, analysis of SAR and DMPK data. Specifically, the primary responsibility of the candidate will be in the lab designing and synthesizing novel chemical compounds to optimize potency, selectivity, pharmacokinetics and in vivo efficacy. As a member of a dynamic, multi-disciplinary team, the selected candidate will collaborate closely with a broad group of scientists within The Scripps Research Institute and contract research organizations (CROs)

Interested applicants should send their curriculum vitae and contact information to Edward Roberts directly at: eroberts@scripps.edu

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Applicants must have PhD in synthetic organic chemistry and be a first author on at least 2-3 publications. This position requires extensive experience in designing synthetic routes for new classes of compounds, solving challenging synthetic problems. Applicants need an expertise in using HPLC, NMR and MS for organic chemistry applications.


This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Michalina Janiszewska
Department: Molecular Medicine
Division: 3
Location: Jupiter, FL
Maildrop: 2A2
Email application materials to: mjaniszewska@scripps.edu
URL: https://www.scripps.edu/janiszewska/
Research Description:

Research description:
Postdoctoral research positions in the field of cancer biology are available in Dr. Michalina Janiszewska’s laboratory, within the Department of Molecular Medicine. Our goal is to understand how intratumor heterogeneity contributes to cancer progression and treatment resistance in highly aggressive brain tumors. Areas of study related to this position include spatial organization of cancer cell subpopulations within a tumor, stem cell hierarchies, and interactions between cancer cells and microenvironment. Our approach involves the development of new technologies, applicable to human tissues and in vivo and in vitro models.


The ideal candidate has experience in cancer biology research, tumor evolution, genetics or epigenetics, is highly motivated, well-organized and eager to work in a highly collaborative team. Candidates with experience in situ techniques, confocal microscopy or mouse models will be preferred. Skills such as image analysis with ImageJ or MatLab, experience with next-generation sequencing data analysis (R language), are also of interest.




Position Requirements: Ph.D. in cancer biology, molecular or cellular biology or related field is required.
Please send a cover letter with a description of your research interests in the laboratory, as well as your CV and contact information for three mentors who will provide reference letters to mjaniszewska@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Tim Spicer
Department: Molecular Medicine
Location: Jupiter, FL
Email application materials to: spicert@scripps.edu
URL: https://www.scripps.edu/research/faculty/spicer
Research Description:

Will be responsible for biochemical and cell-based functional high-throughput screening (HTS) drug-discovery assay development. Perform biochemistry techniques, including protein labeling, expression, and purification. Perform optimization of biochemical & cell-based assays. Operate and troubleshoot automated liquid handling and analytical equipment. Utilize a variety of spreadsheet and data management software systems to generate, analyze, and report data from research efforts.

Position Requirements: Ph.D. in Biology, Chemistry or Engineering sciences. Background in enzyme kinetics, protein expression/purification, mammalian cell culture & cloning. Proficiency with operation of common laboratory and analytical equipment. Ability to work with high content imaging and 3D tissue culture would be a major advantage. Candidates must have excellent communication skills and desire to work in a fast paced, multi-disciplinary collaborative team. Please send C.V. and list of at least 3 professional references to spicert@scripps.edu
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Helen Makarenkova
Department: Molecular Medicine
Location: La Jolla, CA
Maildrop: SR-307
Email application materials to: jcanseco@scripps.edu
URL: http://www.scripps.edu/makarenkova/
Research Description:

To study the FGF signaling during lacrimal gland growth, regeneration, and inflammation. We are interested in the possible contribution of FGF signaling to the stem and progenitor cell survival and in the regulation of lacrimal gland regeneration. We are also interested in developing of new therapeutic approaches to treat dry eye conditions. We are looking for a candidate with a prior molecular biology and biochemistry experience, a record of publications, and some proficiency with bioinformatics. Technical approaches used in the lab FACS cell isolation, include cell culture, real time PCR, western blotting, immunohistochemistry, viral expression, reporter gene expression, gene knockout, RNA-seq, single cell RNA-seq and public database mining.

A Postdoctoral Associate is a direct pay individual in a Division 3 status. Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges.

Please send your CV/Resume to Helen Makarenkova at: hmakarenk@scripps.edu

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Proficiency in molecular biology techniques (RNA-seq or ChIP-seq), FACS analysis and/or primary cell cultures is desired.

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Stuart Lipton
Department: Molecular Medicine
Location: La Jolla, CA
Email application materials to: slipton@scripps.edu
URL: https://www.scripps.edu/lipton/index.html
Research Description:

Postdoctoral position in neurodevelopmental and neurodegenerative diseases using hiPSCs and mouse models.

A postdoctoral position is available in the Lipton lab at The Scripps Research Institute (TSRI) to study neurodevelopmental and neurodegenerative diseases using patient-derived human induced pluripotent stem cells (hiPSCs) as well as genetic mouse models. Our goal is to understand how specific gene mutations and posttranslational modifications that mimic the effect of such mutations, such as aberrant protein S-nitrosylation, contribute to synaptic damage. We also develop new drug therapies for these diseases. Ongoing research in the lab uses “disease-in-a-dish” models generated from hiPSCs in 2D cultures and 3D-brain organoids (“mini-brains”). A plethora of techniques are employed including chemical biology, molecular biology, patch-clamp electrophysiology and calcium imaging.
The candidate is expected to be highly motivated, possess an ability to troubleshoot and work well independently and with others. Tissue culture and molecular biology experience is preferred.

Stuart Lipton, MD, PhD is Professor and Co-Director of the new Neuroscience Translational Center at TSRI. The laboratory is in the Departments of Molecular Medicine and Neuroscience, and is located in the Calibr Building for Drug Discovery on North Torrey Pines Road in La Jolla. We provide competitive salary, fringe benefits and scientific support plus a commitment to helping our trainees advance their careers.

Please send your CV/Resume to Dr. Stuart Lipton at: slipton@scripps.edu

Position Requirements: We are looking for individuals who want to study both transgenic/knock out mouse and hiPSC-based models, and who meet the following criteria:

1) Ph.D. in neuroscience, biology, pharmacology, or a related field.
2) A track record of thoughtful scientific inquiry (e.g., first author publication).
3) Experience at the intersection of two or more of the following fields: Cell biology, molecular biology, biochemistry, confocal imaging/quantitative neurohistology, electrophysiology, pharmacology, data analysis.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Larry Gerace
Department: Molecular Medicine
Division: 3
Location: La Jolla, CA
Maildrop: IMM-10
Email application materials to: lgerace@scripps.edu
URL: http://www.scripps.edu/gerace/
Research Description:

A postdoctoral position is available in the Gerace laboratory for a highly motivated individual to study the role of nuclear envelope proteins in nuclear organization and functions. This project is a component of the NIH 4D nucleome initiative and involves close collaboration with the Yates laboratory at TSRI. Using proteomics, we have identified a group of novel nuclear envelope proteins with potential roles in signaling, nuclear membrane dynamics and gene regulation. The individual will analyze the functions of these proteins in mesenchymal stem cells and determine their roles in adipocyte and myocyte differentiation. The person also will participate in mapping the interactions of these proteins with nuclear lamina and chromosome components. This project is integrated with other studies in the Gerace lab involving animal and cultured cell models that investigate regulation of signaling in the cell nucleus and ER. The collaborative environment at TSRI and the discovery-based nature of this project will foster multidisciplinary thinking, and will provide the potential for advancing expertise in cutting-edge cell biology and imaging technologies.

The candidate must have a strong background in the use of cell and molecular biology techniques for analysis of protein function in mammalian cells. The person should be experienced in generation of mutant gene constructs, implementation of gene knockdown and knockout, and expression of ectopic proteins in mammalian cultured cells by lentiviral and other transduction methods. Experience with immunofluorescence microscopy and light microscope imaging is beneficial.

Interested candidates are asked to send their CV, a statement of research interests and career objectives, and a list of 3 references to Larry Gerace lgerace@scripps.edu.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Ted Kamenecka
Department: Molecular Medicine
Location: Jupiter, FL
Email application materials to: KOBrien@scripps.edu
URL: https://www.scripps.edu/research/faculty/kamenecka
Research Description:

Postdoctoral positions in Medicinal Chemistry are available in the Kamenecka group in The Department of Molecular Therapeutics at the Scripps Research Institute, Florida campus (for more information please see: https://www.scripps.edu/research/faculty/kamenecka). Successful candidates will have a proven track record of publishing in high impact journals and extensive experience in organic synthesis and/or medicinal chemistry, and can work successfully as a member of a team. These full-time lab positions are available starting August 2016.

Position Requirements: Extensive Ph.D. graduate work in multi-step organic synthesis is required, with good laboratory skills and familiarity with modern synthetic techniques and instrumentation (HPLC-MS, HPLC, NMR, chromatography). Strong candidates may also have knowledge and experience in heterocyclic and medicinal chemistry and/or structure-based drug design. Excellent communication skills and interpersonal skills necessary to thrive in a fast-paced team-oriented environment are also required.

Please send CV, research summary, and 3 references to: Kate O’Brien, Scripps Florida, 130 Scripps Way #2A1, Jupiter, FL 33458; or preferably by e-mail: KOBrien@scripps.edu (please include “medicinal chemistry postdoctoral recruiting” in the subject line).

EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Matthew Gill
Department: Molecular Medicine
Location: Jupiter, FL
Email application materials to: mgill@scripps.edu
URL: https://www.scripps.edu
Research Description:

A post-doctoral position is available in the laboratory of Dr Matthew Gill in the Department of Metabolism & Aging at The Scripps Research Institute, Scripps Florida. Work in the lab is focused on characterizing signaling pathways in the nematode C. elegans that are involved in development and lifespan determination. This is being achieved by using an interdisciplinary approach combining genetic, genomic, biochemical and analytical chemistry approaches. The broader significance of this research is to further define the role of these signaling pathways in the etiology of aging and age-related disease and identify new targets for therapeutic intervention.

Position Requirements: Requirements: The position requires a PhD in a related scientific discipline with experience and publications demonstrating expertise in any of the following areas: genetics, molecular biology, protein expression & purification, lipid analysis or cell culture. Experience working with C. elegans and / or a background in aging research would be preferred but is not required.
To be considered, please send a cover letter describing your research interests, your CV, copies of representative publications, and a list of three individuals that can serve as references to Dr. Matthew Gill, mgill@scripps.edu.

For more information, visit www.scripps.edu. TSRI embraces diversity & recognizes it as being a key to our success. EOE/M/F/V/D
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Travis Young (Calibr)
Department: Immunology and Microbiology
Division: 3
Location: La Jolla, CA
Email application materials to: tyoung@calibr.org
URL: www.calibr.org/careers
Research Description:

This position is with the California Institute for Biomedical Research (Calibr). To learn more about this opportunity and/ or to apply for consideration, please go to: www.calibr.org/careers

Job ID: 155
The California Institute for Biomedical Research (Calibr) is a not-for-profit research institute located in La Jolla, California. Calibr is focused on innovative early-stage translational research in the areas of regenerative medicine, cancer biology, cardiovascular and metabolic disease, immunology and infectious disease.

Position Overview:
This postdoctoral fellow will work as part of a small team of interdisciplinary scientists to translate novel cell and protein therapies for the treatment of cancer into human clinical trials. Specifically, the project will focus on the development of next-generation CAR-T cell strategies for the treatment of cancer. This opportunity is ideal for postdocs who are interested in learning the drug discovery process and who want to make an impact by being part of a small dynamic team of scientists working at the cutting edge of cellular immunotherapy.

Essential Duties and Responsibilities:
• Research, design, and execution of cutting-edge programs in cellular and protein sciences.
• Cell biology including working with primary human immune cells and culturing multiple cell lines including, but not limited to, common tumor cell lines used in immuno-oncology research.
• Execution of experiments involving immune cell profiling, cell processing from xenograft models, cytotoxicity, proliferation, activation, cell viability, and survival assays with a strong focus on flow cytometry.
• Generation of reagents for projects including preparation of lentivirus for the transduction of both established cell lines and primary immune cells.
• Molecular biology experiments including DNA and protein preparation from cells, immunoprecipitation, Western blots, etc. will be.
The California Institute for Biomedical Research (Calibr) is a not-for-profit research institute located in La Jolla, California. Calibr is focused on innovative early-stage translational research in the areas of regenerative medicine, cancer biology, cardiovascular and metabolic disease, immunology and infectious disease.
• Preparation of reports and presentation of results at regular team meetings.

Position Requirements: • A strong background in cell culture is essential.
• Experience and knowledge of the immune system are a required. Experience in T cell biology, tumor immunology, as well as other immune components is preferred.
• Hands-on experience with in vitro assays commonly used in immuno-oncology, and experience preparing reagents for in vivo assays. In vivo experience preferred but not required.
• Experience with multi-color flow cytometry and flow data analysis is required.
• Experience with cell transfection and transduction systems is preferred.
• Experience with molecular biology techniques is preferred.
• Experience using Prism, FlowJo, and Office software is important.

Qualifications:
• Ph.D. in biology, chemical biology, biochemistry or related area. Recent Ph.D. graduate or prior postdoctoral experience are both appropriate.
• Impeccable attention to detail, and excellent ability to perform hands-on experiments, research, design, and organize project designs and maintain detailed documentation.
• Highly motivated, creative, and devoted to project goals.
• Able to collaborate proficiently and communicate effectively with colleagues and management teams.
• Able to contribute in a meaningful way to scientific discourse.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Bryan Briney
Department: Immunology and Microbiology
Location: La Jolla, CA
Email application materials to: briney@scripps.edu
Research Description:

The Briney lab combines cutting-edge sequencing technology and computational immunogenetics approaches to investigate protective immune responses to viral infection. We have active research projects in several areas, including HIV, Lassa and Ebola.

We are looking for a postdoc to lead a new systems immunological project focused on Lassa and Ebola. The goals of this project are identifying functional and genetic features in the adaptive immune response that are associated with desirable clinical outcomes. This position is part of a larger initiative with the recently established Center for Viral Systems Biology (https://cvisb.org).

Primary tasks will include:
• Create and improve techniques for large-scale, cost efficient sequencing of adaptive immune receptor repertoire (TCR and BCR).
• Oversee and directly participate in the isolation and characterization of neutralizing monoclonal antibodies from survivors of Lassa and Ebola infection.
• Work closely with computational biologists to develop novel computational tools for evaluation of antibody repertoire development, maturation and function.
Interested candidates should submit their CV and cover letter to briney@scripps.edu. Please have at least three referees email their references directly to briney@scripps.edu.

Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges.

Position Requirements:
Requirements include:
• Ph.D. in immunology, genetics, molecular biology, or similar is required. A pending doctoral degree may be considered with approval of the Principal Investigator.
• Independent, highly motivated and passionate about harnessing emerging technology to answer fundamental questions about viral immunology.
• Familiarity with common molecular biology techniques (cloning, protein production and purification, assessment of antibody binding/neutralization) is highly desirable.
• Experience performing next-generation sequencing is highly desirable, especially experience with the 10X Genomics Chromium platform or other microfluidics-based single cell analysis platforms.
• Experience handing and manipulating large sequence datasets is highly desirable.
• Programming skills in a scripting language (our lab primarily uses Python) are not required but would be a major plus. Although programming proficiency is not required, the ability to assist in the development of novel computational tools by providing immunological guidance and support to computationally-focused lab members is critical.
• Strong interpersonal skills and the ability to work with and mentor junior scientists and students.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Kristian G. Andersen
Department: Immunology and Microbiology
Location: La Jolla, CA
Email application materials to: jobs@andersen-lab.com
URL: https://andersen-lab.com/
Research Description:

Postdoc position in Computational Biology

The Scripps Research Institute is currently seeking a computational Postdoc for the Andersen Lab working in the Department of Immunology and Microbiology. The successful candidate will join an interdisciplinary team of scientists, biologists, clinicians, and computational scientists to apply computational tools to advance the state of the art in quantitative infectious disease research. We are looking for a dedicated individual who will help us transform medicine with a direct impact on global health.

The Andersen lab is working on diverse projects using computational genomics approaches and high-throughput experiments to study emerging viruses and the outbreaks the cause, including Lassa, Ebola, West Nile, and Zika. We use an integrated approach of fieldwork in West Africa, technology development, and computational biology to investigate these viruses.

We are looking for a computational postdoc to lead new projects developing and using data mining, machine learning and Bayesian phylodynamic approaches to investigate the spread and evolution of emerging viruses, including Lassa and Ebola. This position is part of a larger initiative with the recently established Center for Viral Systems Biology (https://cvisb.org/).

Tasks will include:
• Develop novel data mining strategies and deploy computational tools for the exploration of large biological data sets.
• Perform independent research exploring the utility and applications of next-generation sequencing in a global health setting.
• Develop and implement statistical models; work with wet-lab researchers to translate these models into testable experiments; analyze the data produced from these experiments.
• For interested candidates, fieldwork in Sierra Leone is also a possibility.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges

Interested candidates should submit their CV with links to code repositories(Github/Bitbucket) or online demos and cover letter to jobs@andersen-lab.com. Please have at least three referees email their references directly to references@andersen-lab.com.

Position Requirements: Requirements include:
• Ph.D. in computational biology, computer science, mathematics, physics, or equivalent.
• Programming skills in two or more languages (C++/Java/Python/R/MATLAB).
• Experience with data mining and machine learning is highly desired.
• Data visualization in Python/R/d3js is a plus.
• Experience with HPC preferred.
• Deep knowledge of Bayesian statistics, in particular Bayesian phylogenetics is a big plus.
• Strong interpersonal skills and the ability to work with and mentor junior scientists and students.

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Pietro Sanna, M.D.
Department: Immunology and Microbiology
Division: 3
Location: La Jolla, CA
Maildrop: SP30-2300
Email application materials to: psanna@scripps.edu
Research Description:

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member.

A NIH-funded post-doctoral position is available immediately for a motivated individual to join a dynamic multidisciplinary research team at The Scripps Research Institute to study the effects of alcohol and drugs of abuse with electrophysiological methods.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

A background in bio- physics is preferred.

Send CVs & references to psanna@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Pietro Sanna, M.D.
Department: Immunology and Microbiology
Location: La Jolla, CA
Maildrop: SP30-2300
Email application materials to: psanna@scripps.edu
Research Description:

A post-doctoral position is available immediately for a motivated individual to join a dynamic multidisciplinary research team at The Scripps Research Institute to study the neurobiological bases of drug addiction and dementia with strategies involving anatomy, gene expression by RNA-Seq and cell isolation by FACS and laser microdissection, electrophysiology and pharmacology.

This NIH-funded position offers a competitive pay and benefits package.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

MD, PhD or equivalent. Experience in relevant techniques.

Successful candidates will be creative, highly motivated, and able to work semi-independently.

Send CVs & references to psanna@scripps.edu
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Valente
Department: Immunology and Microbiology
Location: Jupiter, FL
Email application materials to: svalente@scripps.edu
URL: http://www.scripps.edu/valente/people.html
Research Description:

Post-Doctoral Position available immediately
Department of Immunology and Microbial Sciences
The Scripps Research Institute in Jupiter, Florida


The Valente laboratory at The Scripps Research Institute – Florida is seeking exceptional candidates for a funded postdoctoral position, available immediately. The laboratory is mainly interested in HIV-1 latency; inhibitors of Tat-activated HIV-1 transcription; HIV-1 mRNA maturation and export; HIV capsid dimerization inhibitors (http://www.scripps.edu/valente/). Studies incorporate cellular and molecular virology, cell biology, primary cell culture, biochemistry, epigenetics and small molecule screening.

Position Requirements: Candidates must possess a Ph.D (or MD/PhD) in virology, molecular biology, cell biology, biochemistry, epigenetics, or immunology, with several international publications. The successful candidate will be expected to work in a BSL3 facility.
Interested candidates should send curriculum vitae, research interest, and the name and contact information of three references to Susana T. Valente, e-mail: svalente@scripps.edu

The Scripps Research institute-Florida (http://www.scripps.edu/florida/)
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Matthew Pipkin
Department: Immunology and Microbiology
Location: Jupiter, FL
Email application materials to: mpipkin@scripps.edu
URL: http://www.scripps.edu/research/cancer-biology/index.html
Research Description:

The transcriptional circuitry of CTL differentiation:
A postdoctoral position within the Department of Cancer Biology is available to study the genetic, molecular and cellular basis of effector and memory CD8+ cytotoxic T lymphocyte (CTL) differentiation. The candidate will develop new, and use available, strains of reporter and gene deficient mice to examine the regulation of effector and memory CTL development in response to model infections and tumors. These approaches will be combined with custom retroviral shRNA-miR libraries targeting transcriptional regulators, in the context of infectious models in vivo and simplified in vitro differentiation systems, to discover and dissect the transcriptional circuitry of CTL differentiation. To clarify important questions underlying cell-differentiation, the candidate will apply sophisticated genetic and molecular approaches such as chromosome transfer, BAC recombineering and transgenesis, and next generation sequencing of RNA and DNA derived libraries.

Position Requirements: The ideal candidate will have a Ph.D. in immunology, a strong background in genetics, and extensive experience with flow cytometry and or fluorescent microscopy. In addition, experience with mice and a committed desire to learn and apply classical and cutting-edge molecular biology approaches are strongly desired.

Interested applicants should submit a CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: mpipkin@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
Principal Investigator Dr. Matthew Pipkin
Department: Immunology and Microbiology
Location: Jupiter, FL
Email application materials to: mpipkin@scripps.edu
URL: http://www.scripps.edu/research/cancer-biology/index.html
Research Description:

The mechanics of nucleosome positioning:
A postdoctoral position within the Department of Cancer Biology is available to study the transcriptional mechanics underlying effector and memory CD8+ T cell differentiation. The candidate’s goals will be to clarify how transcription factor expression levels combined with their affinities for cognate binding sites in DNA control nucleosome positioning and transcription in vivo. The lab has developed and applied novel approaches that integrate bacterial artificial chromosome (BAC) technology and next generation sequencing to map nucleosomes in vivo at unprecedented resolution. A number of genetic tools and approaches are available in the lab to alter expression of essential CD8 T cell specific transcription factors in vitro and in vivo, such as conditional knockout mice, retrovirally expressed cDNAs and whole-genome retroviral shRNA-miR libraries, to examine at the genome-scale how these factors control nucleosome positions and CTL differentiation.

Position Requirements: The ideal candidate will have a Ph.D. in a biological, chemical, or physical science, a quantitative mindset, and a committed desire to learning and applying classical and cutting-edge molecular and biochemical approaches to address the regulation of chromatin and transcription in the immune system.

Interested applicants should submit a CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: mpipkin@scripps.edu.
EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.