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Postdoc Positions

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Principal Investigator Katrin Karbstein
Department: Cancer Biology
Location: Jupiter, FL
Email application materials to: kkarbst@scripps.edu
URL: http://www.scripps.edu/karbstein/Karbstein/Home.html
Research Description:

Postdoctoral Position in Eukaryotic Ribosome Assembly

Research Description: NIH-funded post-doctoral positions are available to study the function of essential proteins required for small ribosomal subunit assembly in yeast, as well as the intersection between 40S ribosome assembly and translational control. A variety of in vitro and in vivo methods, as well as modern systems biology approaches will be used to develop and test models regarding the function of individual assembly factors, providing training opportunities in diverse research techniques. This project is located in Prof. K. Karbstein’s laboratory (http://www.scripps.edu/karbstein/Karbstein/Home.html). Scripps Florida is a dynamic research environment where scientists with both academic and industry experience work collaboratively, ideal for the postdoctoral fellow who is undecided about future career trajectories.

Position Requirements: Applicants with a PhD and published expertise in RNA or protein biochemistry, or yeast genetics and biochemistry will be given close consideration. Funding is in place for 3+ years. Please send a cover letter discussing your interests in the laboratory as well as your CV and list of 3 individuals as references to kkarbst@scripps.edu.
Principal Investigator Tina Izard
Department: Cancer Biology
Location: Jupiter, FL
Email application materials to: cmorrow@scripps.edu
URL: http://www.scripps.edu/florida/cancerbio/izard
Research Description:

Postdoctoral Research Associate positions are immediately available for structure-function studies of cytoskeletal proteins that control signaling downstream of adherens junctions and focal adhesions. Fellows will join an exciting research environment of the Izard laboratory in new state-of-the-art facilities of the Scripps-Florida campus of The Scripps Research Institute (TSRI), which is renowned in the Structural Biology field. The Izard laboratory is recognized as a world leader in the cytoskeleton field.

The position provides an outstanding training program in protein biochemistry and structure, and also in molecular and cellular biology, in a highly dynamic and team-oriented research program. Successful candidates will work in a cutting-edge research environment that tackles this important new arena in cancer and cell biology. The laboratory has outstanding facilities for cell biology, molecular biology, protein expression, purification, and biochemistry, and protein crystallography.

Scripps-Florida provides an incredibly rich scientific environment. Notably, TSRI faculty include an outstanding cadre of senior colleagues, including three Nobel Laureates and about twenty Members of The National Academy of Sciences, including several in crystallography and biophysics. In 2008, Scripps-Florida moved into three new, state-of-the-art research buildings and will expand to eventually house 80 faculty-level investigators. Scripps-Florida has a large cast of outstanding Cores that facilitate basic research and drug development. The unique infrastructure at Scripps-Florida includes the application of unique chemical, genomic, proteomic, informatics, and high-throughput screening and engineering tools for the discovery of novel biomolecules.

Scripps-Florida is a new member of the South East Regional Collaborative Access Team (SER-CAT) that constructed two beam lines at the Advanced Photon Source (APS) at Argonne National Laboratory. The insertion device and bending magnet beam lines are available for all the synchrotron-related data collection needs for the post-doctoral fellows.

Scripps-Florida provides a HighFlux X-ray diffraction system, specifically a Rigaku MicroMax-007 HF, a second-generation true microfocus rotating anode generator. Scripps-Florida also provides an Osmic VariMax optics system and the Proteros Free Mounting System to control the humidity and to optimize diffraction characteristics, including resolution, mosaicity, and anisotropy, as well as reduced X-ray background. Finally, the X-ray laboratory houses the mar345 Image Plate detector.

Palm Beach County is one of the most sought-after communities in the country and offers residents an incomparable lifestyle in a family-friendly community with public playgrounds and parks and access to world-class shopping and unmatched outdoor recreation. It is one of the safest communities in the United States with virtually no crime. The Atlantic Ocean with its 45 miles of spectacular beaches and signature Coconut Palms provides an exclusive getaway in a warm, sunny climate throughout most of the year. There are a number of exquisite art galleries as well as arts and crafts festivals. This golfer’s paradise is also home of the Professional Golfers Association of America (PGA).

Position Requirements: Applicants must have a Ph.D. degree and experience in protein crystallography. Please send CV, a summary of research experience and interests, and names, addresses, e-mail and telephone numbers of 3 references to:

Dr. T. Izard (cmorrow@scripps.edu)
Associate Professor with Tenure
Director, Macromolecular Crystallography Scripps-Florida
Cell Adhesion Laboratory
Department of Cancer Biology
The Scripps Research Institute
Jupiter, FL 33458
Principal Investigator Matthew Pipkin
Department: Cancer Biology
Location: Jupiter, FL
Email application materials to: mpipkin@scripps.edu
URL: http://www.scripps.edu/research/cancer-biology/index.html
Research Description:

The mechanics of nucleosome positioning:
A postdoctoral position within the Department of Cancer Biology is available to study the transcriptional mechanics underlying effector and memory CD8+ T cell differentiation. The candidate’s goals will be to clarify how transcription factor expression levels combined with their affinities for cognate binding sites in DNA control nucleosome positioning and transcription in vivo. The lab has developed and applied novel approaches that integrate bacterial artificial chromosome (BAC) technology and next generation sequencing to map nucleosomes in vivo at unprecedented resolution. A number of genetic tools and approaches are available in the lab to alter expression of essential CD8 T cell specific transcription factors in vitro and in vivo, such as conditional knockout mice, retrovirally expressed cDNAs and whole-genome retroviral shRNA-miR libraries, to examine at the genome-scale how these factors control nucleosome positions and CTL differentiation.

Position Requirements: The ideal candidate will have a Ph.D. in a biological, chemical, or physical science, a quantitative mindset, and a committed desire to learning and applying classical and cutting-edge molecular and biochemical approaches to address the regulation of chromatin and transcription in the immune system.

Interested applicants should submit a CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: mpipkin@scripps.edu.
Principal Investigator Matthew Pipkin
Department: Cancer Biology
Location: Jupiter, FL
Email application materials to: mpipkin@scripps.edu
URL: http://www.scripps.edu/research/cancer-biology/index.html
Research Description:

The transcriptional circuitry of CTL differentiation:
A postdoctoral position within the Department of Cancer Biology is available to study the genetic, molecular and cellular basis of effector and memory CD8+ cytotoxic T lymphocyte (CTL) differentiation. The candidate will develop new, and use available, strains of reporter and gene deficient mice to examine the regulation of effector and memory CTL development in response to model infections and tumors. These approaches will be combined with custom retroviral shRNA-miR libraries targeting transcriptional regulators, in the context of infectious models in vivo and simplified in vitro differentiation systems, to discover and dissect the transcriptional circuitry of CTL differentiation. To clarify important questions underlying cell-differentiation, the candidate will apply sophisticated genetic and molecular approaches such as chromosome transfer, BAC recombineering and transgenesis, and next generation sequencing of RNA and DNA derived libraries.

Position Requirements: The ideal candidate will have a Ph.D. in immunology, a strong background in genetics, and extensive experience with flow cytometry and or fluorescent microscopy. In addition, experience with mice and a committed desire to learn and apply classical and cutting-edge molecular biology approaches are strongly desired.

Interested applicants should submit a CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: mpipkin@scripps.edu.
Principal Investigator Min Guo
Department: Cancer Biology
Location: Jupiter, FL
Email application materials to: guomin@scripps.edu
URL: http://intranet.scripps.edu/research/cancer-biology/index.html
Research Description:

The Scripps Research Institute is currently seeking a Postdoctoral fellow to work in the laboratory of Dr. Min Guo in the Department of Cancer Biology at the Florida Campus. The lab is focused on the structural and cell biology of aminoacyl tRNA syntheses and their related pathways.

Postdoctoral Research Associate position in cancer immunology: The fellow will be involved in studies of tumorigenesis and immune therapy, using cell culture, bioinformatics, small molecule screening, mice model, imaging, and proteomics to identify novel functional regulation of human aminoacyl tRNA synthetase in cancer therapy.

Position Requirements: Applicants must be highly motivated with strong interest in Science. Successful experience of PhD in a relevant scientific discipline and proficiency in structural biology, immunology, molecular and cellular biology is required.

Please send your CV and a list of 3 professional references to guomin@scripps.edu.
Lab website: www.scripps.edu/guo/
Principal Investigator Min Guo
Department: Cancer Biology
Location: Jupiter, FL
Email application materials to: guomin@scripps.edu
URL: http://intranet.scripps.edu/research/cancer-biology/index.html
Research Description:

The Scripps Research Institute is currently seeking a Postdoctoral fellow to work in the laboratory of Dr. Min Guo in the Department of Cancer Biology at the Florida Campus. The lab is focused on the structural and cell biology of aminoacyl tRNA syntheses and their related pathways.

Postdoctoral Research Associate position in protein biophysics: The fellow will be involved in projects focused on structural analysis of human aminoacyl tRNA synthetase related bio-reporter. An appropriate post doctoral fellow candidate would have experience in biochemistry, protein engineering and x-ray crystallography.

Position Requirements: Applicants must be highly motivated with strong interest in Science. Successful experience of PhD in a relevant scientific discipline and proficiency in structural biology, immunology, molecular and cellular biology is required.

Please send your CV and a list of 3 professional references to guomin@scripps.edu.
Lab website: www.scripps.edu/guo/
Principal Investigator Kerri A. Mowen
Department: Chemical Physiology
Division: 3
Location: La Jolla, CA
Maildrop: IMM-11
Email application materials to: kmowen@scripps.edu
URL: http://www.scripps.edu/mowen/
Research Description:

A postdoctoral position for an enthusiastic, motivated, and independent individual is available in our lab. Expertise in molecular biology, protein purification, biochemistry, and immunobiology is highly advantageous. Organizational skills are a must.

Interested candidates should submit their CV and a list of at least 3 professional references to kmowen@scripps.edu.

Position Requirements: Ph.D. in molecular biology, immunology, biochemistry, or cell biology is required. Good communication and organizational skills are a must.

A pending doctoral degree may be considered with approval of the Principal Investigator.
Principal Investigator Edward Roberts
Department: Chemistry
Division: 3
Location: La Jolla, CA
Maildrop: SP-3156
Email application materials to: eroberts@scripps.edu
Research Description:

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Must have extensive work in multi-step organic synthesis; with good laboratory skills and familiarity with modern synthetic techniques and instrumentation (HPLC-MS, HPLC, NMR, chromatography). Strong candidates may also have knowledge and experience in heterocyclic and desire to learn medicinal chemistry and/or structure-based drug design. Excellent communication skills and interpersonal skills necessary to thrive in a fast-paced team-oriented environment are also required. This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Interested parties should email their CV and a description of their research interests to Prof. Edward Roberts at eroberts@scripps.edu along with three letters of reference forwarded on their behalf.
Principal Investigator Chi-Huey Wong
Department: Chemistry
Location: La Jolla, CA
Maildrop: BCC-338
Email application materials to: wong@scripps.edu
URL: http://www.scripps.edu/wong/
Research Description:

Postdoctoral Research Fellowship in the Wong Lab. Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting RNA and design and synthesis of inhibitors to enzymes and receptors are being performed to investigate how small molecules interact with biologically important molecules and in turn, learn more about the function of those molecules.

Position Requirements: Candidates with Ph.D. training in synthetic organic or chemical biology, especially related to glycoscience will be considered. The research project is concerning with development of inhibitors against drug resistant bacterial transglycosidase and influenza surface enzymes/proteins and design of carbohydrate-based vaccines.

Basic knowledge in basic lab procedures & chemical management practices & safety; basic understanding of protein purification and organic synthesis. Also a basic understanding of all biochemical laboratory equipment. Ability to learn new techniques and following instructions.
Principal Investigator Ram Krishnamurthy
Department: Chemistry
Division: 3
Location: La Jolla, CA
Maildrop: MB-16
Email application materials to: rkrishna@scripps.edu
URL: http://www.scripps.edu/krishnamurthy/
Research Description:

Postdoctoral Research Fellowship in the Krishnamurthy Lab. Research in the Krishnamurthy lab encompasses a broad spectrum of synthetic chemistry and methodology applied to understanding the chemistry associated with emergence of RNA. This project involves the synthesis and investigation of oligonucleotides with alternative backbones.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Qualified candidates should have a PhD in organic chemistry and be well grounded in analytical techniques. The applicant should have a synthetic organic chemistry background with a strong emphasis in nucleic acid and oligonucleotide chemistry, coupled with experience in analytical techniques (e.g. HPLC). The applicant should read the following papers (Chem. Eur. J. 2013, 19, 15336-15345. Angew. Chem. Int. Ed. 2013, 52, 5840-5844 Synlett, 2014, 25, 1511-1518) as the projects he/she will be involved in will be along these lines. This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Interested parties should email their CV and a description of their research interests to Prof. Ram Krishnamurthy at rkrishna@scripps.edu and should have three letters of reference forwarded on their behalf. Applicants should, in their cover letter, address what their scientific interests and goals are and how (a) they align with this specific project and (b) this position would help in attaining the long term goals. Looking for candidate to start as soon as possible.
Principal Investigator Matt Disney
Department: Chemistry
Location: Jupiter, FL
Email application materials to: disney@scripps.edu
URL: http://www.scripps.edu/research/faculty/disney
Research Description:

The Disney Lab at Scripps Florida has multiple openings for postdoctoral candidates in the area of rational design of small molecules targeting RNA.

The selected candidate(s) will conduct research in using a combination of approaches to rationally design small molecules targeting RNA (J. Am. Chem. Soc. 2012, 134(10): 4731-4742; ACS Chem. Biol. 2012, in press; and, ACS Chem. Biol. 2012, 7(3): 496-505). Several compounds have been successfully developed to target repeating RNA transcripts that cause diseases such as Myotonic Dystrophy, Huntington’s Disease, et cetera. We are seeking qualified individuals to contribute to future developments in this area including: (i) using a library-versus-library screen to identify and annotate RNA-ligand interactions (described in J. Am. Chem. Soc. 2011, 133(26): 10111-10118 and Angew. Chem. Int. Ed. Engl. 2010, 49(22): 3816-3818); (ii) using computationally approaches (RNA structure modeling) to identify new RNA targets for small molecules from human genomic sequence; and, (iii) further develop lead bioactive compounds in a variety of cellular and animal model systems.

Our laboratory is located at The Scripps Research Institute in Jupiter, Florida. Students interested in careers in academia or in industry are well suited for these positions. Scripps Florida houses high throughput screening, DMPK, and other facilities that uniquely position us for translational research.

Position Requirements: Qualified candidates should have a PhD in a related scientific discipline and an established background in Bioorganic Chemistry or Chemical Biology. Previous experience in RNA folding, RNA biochemistry/biophysics, or nucleic acids biochemistry/biophysics would be helpful, but is not essential.

Interested parties should email their CV and a description of their research interests to Prof. Matt Disney at Disney@scripps.edu and should have three letters of reference forwarded on their behalf. More information about this position and the laboratory can be found at http://www.scripps.edu/disney/.
Principal Investigator Brian Paegel
Department: Chemistry
Location: Jupiter, FL
Email application materials to: briandna@scripps.edu
Research Description:

A postdoctoral fellowship is available in synthetic biology, cell-based screening, and lipid bilayer vesicle assembly in the laboratory of Prof. Brian Paegel at The Scripps Research Institute in Jupiter, FL.

Scripps Florida is a dynamic research environment where scientists with both academic and industry experience work collaboratively, ideal for the postdoctoral fellow who is undecided about future career trajectories.

Position Requirements: To be considered, applicants must have a doctoral degree and published expertise in a
subset of fields including microfluidics, liposome/GUV synthesis and analysis, and membrane protein biochemistry.

If you are interested in joining our highly interdisciplinary team, please submit your cover letter, CV and a sample publication to Dr. Brian Paegel, briandna@scripps.edu.
Principal Investigator Kate Carroll
Department: Chemistry
Location: Jupiter, FL
Email application materials to:
URL: http://www.scripps.edu/research/faculty/carroll
Research Description:

The Carroll lab in the Department of Chemistry at Scripps, Florida currently has NIH-funded postdoctoral positions available in the areas of Cellular and Molecular Biology, Chemical Biology and Synthetic Chemistry.

Position Requirements: Candidates should possess a PhD in a related scientific discipline.

Postdoctoral candidates should send an inquiry with their CV and have three references send letters of recommendation to kcarroll@scrippps.edu.

In the application / cover letter, please address the following: (1) What are your scientific goals and interests, and how might your graduate research background be leveraged to create synergy with the strengths of our laboratory? (2) What, if any, are your plans for obtaining postdoctoral fellowship funding? (3) What are your long-term career plans as of today? Complete applications with published experience in the above focus areas will be given priority.
Principal Investigator Eric Zorrilla
Department: Committee on the Neurobiology of Addictive Disorders
Location: La Jolla, CA
Maildrop: SP30-2400
Email application materials to: ezorrilla@scripps.edu
URL: http://www.scripps.edu/zorrilla
Research Description:

A post-doctoral position is available for a highly motivated individual to join the Zorrilla lab at The Scripps Research Institute to study the neurobiology of reward and stress circuits relevant to the pathophysiology and treatment of emotional disorders, compulsive eating, obesity, and alcoholism. Competitive candidates for this NIH-funded position will be highly creative, motivated and self-sufficient.

For more details on our areas of interest, please see the lab webpage at www.scripps.edu/zorrilla.

Position Requirements: Applicants will have a PhD, MD or equivalent degree with strong conceptual and experimental background in molecular biology, neuroscience, pharmacology, endocrinology, or a related discipline. Experience in optogenetics or epigenetics is preferred. Qualified applicants should submit a CV, summary of research accomplishments and interests, and names of three references to Dr. Eric Zorrilla at ezorrilla@scripps.edu.
Principal Investigator Jiang Zhu
Department: Immunology and Microbial Science
Location: La Jolla, CA
Maildrop: IMM-25
Email application materials to: jiang@scripps.edu
Research Description:

Successful applicants will participate in exciting research projects including but not limited to: (1) Vaccine design: next-generation sequencing will be used to identify new broadly neutralizing antibodies and to understand the mechanism of antibody maturation. Computational tools will be employed to analyze antibody-antigen complexes and to design novel immunogens, which will be characterized experimentally and tested in animal experiment; (2) Optogenetics: novel strategies will be developed to design and engineer optical proteins to control the function of critical components involved in signaling pathways and circuits implicated in neurodegenerative diseases; (3) Structure-function study of molecular complexes: experimental data obtained from various experimental techniques, for example cryo-electron microscopy (cryo-EM), will be incorporated into structural modeling and simulation to understand structure-function relationship of large molecular assemblies.

Successful applicants will have the opportunity to work with multiple experimental groups at TSRI (for vaccine design: http://chavi-id.org/ and http://www.scripps.edu/research/ims/; for other research areas: http://www.scripps.edu/research/iscb/) and elsewhere.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
For the experimental position, we are seeking motivated candidates with training in molecular biology, biochemistry, protein characterization and structural biology; for the computational position, we are seeking motivated candidates with experience in next-generation sequencing, protein structure prediction, and molecular simulation.

For consideration: please send a current CV and 3 letters of reference to jiang@scripps.edu
Principal Investigator Jiang Zhu
Department: Immunology and Microbial Science
Location: La Jolla, CA
Maildrop: IMM-25
Email application materials to: jiang@scripps.edu
Research Description:

Successful applicants will participate in exciting research projects including but not limited to: (1) Vaccine design: next-generation sequencing will be used to identify new broadly neutralizing antibodies and to understand the mechanism of antibody maturation. Computational tools will be employed to analyze antibody-antigen complexes and to design novel immunogens, which will be characterized experimentally and tested in animal experiment; (2) Optogenetics: novel strategies will be developed to design and engineer optical proteins to control the function of critical components involved in signaling pathways and circuits implicated in neurodegenerative diseases; (3) Structure-function study of molecular complexes: experimental data obtained from various experimental techniques, for example cryo-electron microscopy (cryo-EM), will be incorporated into structural modeling and simulation to understand structure-function relationship of large molecular assemblies.

Successful applicants will have the opportunity to work with multiple experimental groups at TSRI (for vaccine design: http://chavi-id.org/ and http://www.scripps.edu/research/ims/; for other research areas: http://www.scripps.edu/research/iscb/) and elsewhere.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

For the experimental position, we are seeking motivated candidates with training in molecular biology, biochemistry, protein characterization and structural biology; for the computational position, we are seeking motivated candidates with experience in next-generation sequencing, protein structure prediction, and molecular simulation.

For consideration: please send a current CV and 3 letters of reference to jiang@scripps.edu

Principal Investigator Ann Fenney
Department: Immunology and Microbial Science
Division: 3
Location: La Jolla, CA
Maildrop: IMM-22
Email application materials to: feeney@scripps.edu
URL: http://www.scripps.edu/ims/feeney/
Research Description:

A postdoctoral position is available for a highly motivated candidate with strong molecular biology skills. Our lab studies the epigenetic, genetic and transcriptional control of V(D)J rearrangement, B cell repertoire formation, and B cell differentiation. Utilizing ChIP-seq, RNA-seq, and chromosome conformation capture (3C) approaches, we study the 3-dimensional changes which take place in the immunoglobulin loci during V(D)J rearrangement, and the transcription factors which control these changes. Using deep sequencing, we study how these changes affect the composition of the resulting antibody repertoire. Transcriptional regulation of later stages of B cell differentiation is also being investigated.

Position Requirements: Candidates with a Ph.D. and/or M.D. and with a strong background in molecular biology are encouraged to apply. Interested candidates should submit their CV and the names and contact information for at least three professional references to feeney@scripps.edu.
Principal Investigator Michael Zwick
Department: Immunology and Microbial Science
Division: 3
Location: La Jolla, CA
Maildrop: IMM-33
Email application materials to: zwick@scripps.edu
URL: http://www.scripps.edu/research/ims/
Research Description:

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Individual will study the molecular properties and immunogenicity of the HIV-1 envelope glycoproteins. We are interested in identifying HIV-1 envelope spikes with enhanced stability and affinity for relevant neutralizing antibodies, to be evaluated as vaccine leads.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Additional assets include experience with animal models, flow cytometry, high-throughput methods, protein expression, antibody engineering, HIV-1, B cell development, molecular modeling and computational skills. The successful candidate must be highly motivated, work effectively with others, have excellent writing skills, and be able to troubleshoot. Applicants are encouraged to indicate on their cover letter why they are uniquely suited for the position.

For consideration please send your CV, cover letter and two professional references to: zwick@scripps.edu
Principal Investigator Choe, Farzan, Lasmezas, Tellinghuisen, Valente
Department: Infectious Diseases
Location: Jupiter, FL
Email application materials to: IDsearch@scripps.edu
URL: http://www.scripps.edu/florida/research/infectious-diseases/index.html
Research Description:

Postdoctoral fellowships in Microbiology and Infectious Diseases
The Scripps Research Institute, Scripps Florida

The Department of Infectious Diseases at The Scripps Research Institute in Jupiter, Florida is hiring new post-doctoral fellows in the following areas:

Flaviviruses and emerging pathogens (Dr. Hyeryun Choe)
HIV-1 antibody evolution and vaccine development (Dr. Michael Farzan)
Neurodegenerative diseases of prions and other transmissible proteins (Dr. Corinne Lasmezas)
Hepatitis C replication and host interactions (Dr. Tim Tellinghuisen)
HIV-1 latency and the cure (Dr. Susana Valente)

The Department of Infectious Diseases is part of the highly collaborative research environment on the beautiful Florida campus, with exceptional resources in proteomics, genomics, drug discovery, and medicinal chemistry. Qualified candidates may be eligible for a two-year Institute Fellowship. Send CV and a cover letter indicating primary area of research interest by September 10th to IDsearch@scripps.edu.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
Principal Investigator Dr. Anutosh Chakraborty
Department: Metabolism and Aging
Location: Jupiter, FL
Email application materials to: achakrab@scripps.edu
Research Description:

A postdoctoral position is immediately available in the Chakraborty laboratory for a highly enthusiastic and motivated individual to study the role of inositol pyrophosphates and their biosynthetic enzymes in metabolism. IP6K1 deletion protects mice against high fat diet induced weight gain and related metabolic aberrations (Chakraborty et al. Cell, 2010, 143, 897; Chakraborty et al. Sci. Signal. 2011, 4, re1). Using whole body and tissue specific knockout mice; pharmacology; and cellular-biochemical approaches; our laboratory currently explores the molecular mechanism/s by which IP6K1 regulates glucose and lipid homeostasis. The ultimate goal is to develop potent and safe drugs that ameliorate obesity and diabetes via interfering with IP6K1 functions in vivo.

Position Requirements: Candidates with a Ph.D. in molecular biology, biochemistry or cell biology are encouraged to apply. Expertise in enzymology, pharmacology, biochemistry and molecular biology is strongly desirable. Applicant having experience in metabolism research will be preferred. We are looking for the selected candidate to start by December 1, 2014.


The Department of Metabolism and Aging is part of the highly collaborative research environment on the beautiful Florida campus, with exceptional resources in proteomics, genomics, drug discovery, and medicinal chemistry. Applicants should send CV and a cover letter indicating his/her primary area of research interest with names, addresses and contact information of three references to achakrab@scripps.edu.





Principal Investigator Dr. Laura Niedernhofer
Department: Metabolism and Aging
Location: Jupiter, FL
Email application materials to: ariggs@scripps.edu
URL: http://www.scripps.edu/research/faculty/niedernhofer
Research Description:

A Postdoctoral Research Associate position is immediately available in the laboratory of Laura Niedernhofer. Our research program is focused on investigating the underlying causes of aging. We use mouse models extensively, employing both genetics and pharmacology to interrogate mechanisms of aging. In addition, aging is investigated in vitro by measuring senescence of primary cells or function of adult stem cells. The Fellow will join an exciting research environment in the Department of Metabolism and Aging in the new state-of-the-art facilities of the Scripps Florida campus of The Scripps Research Institute (TSRI) in Jupiter, Florida. The position offers exceptional training in aging, aging-related degenerative diseases, cellular senescence, DNA damage and repair and molecular therapeutics.

Position Requirements: Applicants must have a Ph.D. degree, experience in molecular and cellular biology, and interest in working with murine models of disease. Special attention will be given to applicants with significant experience in cloning, mammalian cell culture, protein biochemistry, metabolism and/or mitochondrial biology. Please send a CV, including a summary of research experience and interests, along with contact information for 3 references to ariggs@scripps.edu.
Principal Investigator Sandra Encalada
Department: Molecular and Experimental Medicine
Location: La Jolla, CA
Maildrop: MEM-215
Email application materials to: encalada@scripps.edu
URL: http://www.scripps.edu/encalada/
Research Description:

A postdoctoral position is available in the Encalada Laboratory at The Scripps Research Institute in La Jolla, California, USA, in the areas of neurodegeneration, aging, and intracellular transport. Our lab is interested in characterizing the mechanisms of regulation of molecular motor-driven transport in neurons and the role that defective transport plays in neurodegeneration and aging, with an emphasis on prion, Alzheimer’s and other aggregation-associated degenerative diseases. We use a combination of cell biology, genetics, biochemistry, and high-resolution quantitative microscopy in mammalian neurons and in C. elegans to address these research areas, and possible projects include characterization of model organism models of neurodegenerative diseases.

Position Requirements: You are about to complete your PhD or have completed your PhD within the last year in cell biology, genetics, neurobiology, molecular biology, biophysics, or related field.
Preferred candidates are highly motivated, independent, with outstanding written and oral communication skills, and ideally with peer-reviewed publications. Plus research experience with C. elegans and/or cell culture, and with light microscopy is preferred but not required.

Interested candidates please send a CV with a list of publications, a brief statement of your previous research expertise, future interests, and the contact information of three references to Sandra Encalada at encalada@scripps.edu. For more information also please consult our website at http://www.scripps.edu/encalada/encalada/HOME.html
Principal Investigator Bruce E. Torbett
Department: Molecular and Experimental Medicine
Location: La Jolla, CA
Maildrop: MEM-131
Email application materials to: betorbet@scripps.edu
URL: http://www.scripps.edu/torbett/
Research Description:

The Torbett group is developing and validating novel methods for lentiviral vector gene delivery to human hematopoietic stem cells as well as the development human of hematopoietic stem cells from iPSCs.

We are soliciting applications from individuals that have a recent PhD and/or MD, which is within 2 years of your advanced degree. Applicants with experience in multicolor flow cytometry, cell culture of primary hematopoietic cells, cell biology (autophagy or endocytic pathways training), hematology, viral entry with an emphasis on endocytic pathways, and/or standard molecular techniques and mouse use are preferred. If applying to study in the area of iPSC biology, training in the use of ES or iPSCs, hematology, flow cytometry, and mouse use experience is preferred.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Please provide a C.V., which outlines your research background, publications, and 3 letters of recommendation.
Principal Investigator Laurent Mosnier
Department: Molecular and Experimental Medicine
Location: La Jolla, CA
Maildrop: MEM-180
Email application materials to: lmosnier@scripps.edu
URL: http://vivo.scripps.edu/display/MosnierLaurent
Research Description:

We are seeking a highly motivated PhD or PhD/MD to work in a translational hemostasis and thrombosis research lab. The ideal candidate will have a strong background in protein biochemistry and protein purification, molecular biology, and have experience in biological techniques as they apply to coagulation research. Our research goals are to study novel, newly engineered clotting factor compounds for their effects on hemostasis and fibrinolysis. The candidate should be able to take initiative and capable of working independently with appropriate supervision and guidance. He or she will be responsible for recombinant protein production in mammalian cells, protein purification, in vitro characterization of engineered compounds in coagulation assays and in vivo proof-of-principle studies. Expertise in protein biochemistry is paramount. This postdoctoral fellowship will provide a unique opportunity to advance into the biological aspects of hemostasis and thrombosis by studying novel compounds and paradigms in biological assays and in animal models. The fellow will work with mice and human samples and develop a strong translational component for application in human disease.

Position Requirements: Must possess a doctoral degree with primary research focus in protein biochemistry, protein engineering, and purification, molecular biology, mammalian tissue culture, coagulation assays, murine in vivo studies, and translational science. Strong written and verbal communication skills are essential.

Interested applicants should submit a current CV and 3 professional references.
Principal Investigator Dennis Wolan
Department: Molecular and Experimental Medicine
Division: 3
Location: La Jolla, CA
Maildrop: MEM-L71
Email application materials to: wolan@scripps.edu
URL: http://www.scripps.edu/wolan/
Research Description:

A shared postdoctoral position is immediately available in the laboratories of Profs. Ian Wilson (Department of Structural and Computational Biology) and Dennis Wolan (Department of Molecular and Experimental Medicine). The project requires a significant background in peptide and organic synthesis and will require the individual to employ a variety of biophysical and cellular methods as platforms towards the discovery and iterative design of small molecule inhibitors of viral infections.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Applicants should preferably have a Ph.D. in organic synthesis and drug discovery with knowledge of molecular biology, cellular biology and protein structure. A pending doctoral degree may be considered with approval of the Principal Investigator. Successful candidates will work in a multidisciplinary research environment that greatly facilitates target discovery and lead compound discovery and optimization. TSRI provides a highly collaborative environment with outstanding synthetic and medicinal chemistry, chemical biology, structural biology and high-throughput screening facilities.

Interested applicants should submit a CV, a brief statement of research experience, goals and contact information (email address and phone number) of three references to wolan@scripps.edu.
Principal Investigator Dr. Laura solt
Department: Molecular Therapeutics
Location: La Jolla, CA
Email application materials to: lsolt@scripps.edu
Research Description:

A Postdoctoral position within the Department of Molecular Therapeutics is available to study the transcriptional control of CD4+ T helper cell populations by the nuclear hormone receptors, the REV-ERBs, in the context of autoimmunity. The candidate will use developed novel REV-ERB specific chemical ligands and genetic mouse models to explore and characterize the molecular mechanism of REV-ERB regulation of Th17 cell development and function both in vitro and in vivo. The overall significance of our research is to better define the roles for the REV-ERBs in Th17-mediated autoimmunity in order to design more efficacious and potent small molecules targeting the REV-ERBs for the treatment of autoimmune diseases.

Position Requirements: The ideal candidate will have a Ph.D. in Immunology, a strong background in Molecular Biology, and have extensive skills with flow cytometry. The candidate should possess excellent organizational, written, and oral communication skills. Experience with mice and a committed desire to learn and apply cutting edge chemical biology and biochemical approaches is strongly desired.
Interested applicants should submit a CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: lsolt@scripps.edu.

Principal Investigator Douglas Kojetin
Department: Molecular Therapeutics
Location: Jupiter, FL
Email application materials to: dkojetin@scripps.edu
URL: http://www.scripps.edu/research/faculty/kojetin
Research Description:

Postdoctoral Position in Nuclear Receptor Structural Pharmacology
Our lab focuses on structure-function relationships and the role of protein dynamics in activation of nuclear receptors by small molecule ligands, including natural ligands and synthetic ligands (drugs).
We are seeking motivated postdoctoral candidates with expertise in one or both of the following areas:
- structural biology, x-ray crystallography (preferred) or NMR spectroscopy
- molecular/cell biology or pharmacology

Position Requirements: Ph.D. in a relevant scientific discipline with expertise in structural biology and/or molecular/cell biology or pharmacology. Funding is in place through an imminent 5 year NIH grant award. For consideration, send a cover letter stating your research and career interests, a CV and contact information for 3 references to dkojetin@scripps.edu.
Principal Investigator Dr. Derek Duckett
Department: Molecular Therapeutics
Location: Jupiter, FL
Email application materials to: ducketdr@scripps.edu
Research Description:

An early career post-doctoral position is available at TSRI to apply genetic and cell biology approaches to elucidate novel cell signaling mechanisms involved in tumor progression and metastasis.

Position Requirements: Applicants with a strong background in molecular biology and in vivo experience using tumor xenograft models will be given close consideration. The Department of Molecular Therapeutics at Scripps Florida is comprised of a unique environment wherein researchers with both academic and industry experience work collaboratively. Integration between chemistry, DMPK, target validation and in vivo testing provide multidisciplinary training within this environment.

You should have a PhD and be highly motivated to pursue a career in Translational Science.

Please send Curriculum Vitae, a summary of research experience and interests, and names, addresses, e-mail and telephone numbers of 3 references to:

Dr. Derek Duckett (ducketdr@scripps.edu)
Associate Scientific Director,
Translational Research Institute,
Dept.of Molecular Therapeutics
The Scripps Research Institute
130 Scripps Way #2A2
Jupiter, FL 33458
Principal Investigator Philip LoGrasso
Department: Molecular Therapeutics
Location: Jupiter, FL
Email application materials to: mtelling@scripps.edu
URL: http://www.scripps.edu/research/faculty/lograsso
Research Description:

The Department of Molecular Therapeutics at The Scripps Research Institute, Scripps Florida, is seeking a post doctoral candidate with experience in neurobiology, cell biology, molecular biology, and biochemistry. The project is centered on oxidative stress and neurodegeneration both in vitro and in vivo and is trying to delineate aspects of both mitochondrial dysfunction and ER stress. Our lab has a significant focus on kinases, with a particular interest in JNK, LRRK2, and SGK-1. The candidate will be responsible for investigating the role of mitochondrial JNK signaling, how LRRK2 interacts with the JNK pathway, and how SGK-1 may affect LRRK2.

Interested applicants are encouraged to submit a curriculum vitae and the names and contact information for three references to: Dr. Philip LoGrasso, TSRI, mtelling@scripps.edu.

Position Requirements: The ideal candidate will have a Ph.D. in Neuroscience, Cell Biology, or Biochemistry or a related field and have demonstrated expertise in all of the areas listed above. Detailed knowledge of mitochondrial functional assays, immunocytochemistry, isolation of primary neurons, and apoptotic and cytotoxicity assays is required. Experience in stereotactic surgery and confocal microscopy is a plus.
Principal Investigator Dr Derek Duckett
Department: Molecular Therapeutics
Location: Jupiter, FL
Email application materials to: ducketdr@scripps.edu
Research Description:

An early career post-doctoral position is available at TSRI to apply kinase-based biochemistry and cell biology approaches to seek novel anti-cancer agents. The infrastructure at Scripps Florida includes unique chemical, genomic, proteomic, informatics, and high-throughput screening tools for the discovery of novel small molecules. Opportunities for in vitro and in vivo validation studies will be available to the motivated candidate.


Position Requirements: Applicants with a strong background in biochemistry and molecular biology will be given close consideration. The Department of Molecular Therapeutics at Scripps Florida is comprised of a unique environment wherein researchers with both academic and industry experience work collaboratively. Integration between chemical development, high throughput screening, target validation and in vivo testing provide multidisciplinary training within this environment.

You should have a PhD and be highly motivated to pursue a career in Translational Science.

Please send Curriculum Vitae, a summary of research experience and interests, and names, addresses, e-mail and telephone numbers of 3 references to:

Dr Derek Duckett (ducketdr@scripps.edu)
Associate Scientific Director,
Translational Research Institute,
Dept of Molecular Therapeutics
The Scripps Research Institute
130 Scripps Way #2A2
Jupiter, FL 33458

Principal Investigator Scott B. Hansen
Department: Molecular Therapeutics
Location: Jupiter, FL
Email application materials to: shansen@scripps.edu
URL: http://www.scripps.edu/research/faculty/hansen
Research Description:

Postdoctoral Position in Ion Channels Electrophysiology and Mechanosensation
The Scripps Research Institute, Florida

Postdoctoral candidates with interests in Molecular Neuroscience, Drug Discovery, Molecular Pharmacology, or Cell Signaling are encouraged to apply for a position at the Scripps Research Institute in the laboratory of Dr. Scott B. Hansen.

Scripps is a world-class biomedical research institute with a new state-of-the-art campus adjacent to the Max Planck Institute in Jupiter, Florida. Successful candidates will join a vibrant scientific community of drug discovery and neuroscience while enjoying the pristine beaches and desirable weather of Florida.

The position will focus on mechano sensitive ion channels and the molecular sensor for mechanical force. A generous 5-year NIH New Innovator Award funds this project. Successful applicants will make fundamental discoveries in mechanosensation and develop cutting edge techniques in molecular neuroscience.

Position Requirements: Applicants should have completed a Ph.D. in a biological science, be motivated, and have demonstrated prior laboratory experience with protein biochemistry. Experience with electrophysiology is most desirable followed by cell signaling, molecular biology, lipids, or pharmacology.
Principal Investigator Damon Page
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: paged@scripps.edu
URL: http://www.scripps.edu/research/faculty/page
Research Description:

A postdoctoral position is available in the Page laboratory in the Department of Neuroscience to investigate the role of genetic risk factors for autism in the development and function of neuronal cell types involved in behavior, using mouse as a model system. The goal of the project is to understand principles of neural circuit assembly and the influence of autism risk factors on this process at the molecular, structural and behavioral levels. For information about the laboratory, please visit: www.scripps.edu/florida/neuro/page.html

Position Requirements: Requirements: In addition to a PhD in a related discipline, highly motivated candidates must have expertise in genetics, molecular/cell biology, imaging and/or behavioral neuroscience. Interested candidates should send a cover letter, CV and contact details for three references to Damon Page, Ph.D., email: paged@scripps.edu.

TSRI embraces diversity & recognizes it as being a key to our success. EOE/M/F/V/D
Principal Investigator Ron Davis
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: rdavis@scripps.edu
URL: http://www.scripps.edu/research/faculty/davis
Research Description:

Currently seeking Postdoctoral Research Associates who will work on projects involving the molecular and cellular biology of memory formation in Drosophila and the mouse using genetic, molecular, cellular, anatomical and behavioral approaches. In addition, selected individuals may perform translational research on mood disorders and Alzheimer's disease.

Position Requirements: PhD in a relevant scientific discipline and experience with research projects that employ diverse techniques and address questions that range from the molecular to the behavioral is required.

To be considered, submit Curriculum Vitae and complete contact information for at least three professional references as a single PDF file, to rdavis@scripps.edu.
Principal Investigator Kirill Martemyanov
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: kirill@scripps.edu
URL: http://www.scripps.edu/martemyanov
Research Description:

Molecular and Cellular Neurobiology of GPCR Systems

An NIH funded postdoctoral position is available within the Jupiter, FL campus to study molecular, cellular and behavioral aspects of neuronal signaling. We are looking for an energetic colleague with keen interest in science and solid background in the areas of physiology, molecular and cell biology.

The laboratory is interested in delineating mechanisms by which GPCR pathways control reward behavior, vision and provide neural control of the cardiac function. It is expected that the project will contribute to our understanding of the neuropsychiatric diseases, drug addiction and vision loss while focusing on the discovery of the fundamental neurobiological principles. Multidisciplinary approach integrating behavioral characterization of genetic mouse models with live cell imaging, biochemical analysis of signaling reactions and discovery of novel interactions by mass-spectrometry assisted proteomics is envisioned. For details visit the website of the laboratory at http://www.scripps.edu/martemyanov.

Position Requirements: Requirements: PhD in a related scientific discipline and experience with electrophysiological approaches and/or genetic mouse models for investigation of cardiovascular function is required. An energetic colleague with keen interest in science and solid background in the areas of physiology, molecular and cell biology is strongly desired.

To be considered, please send CV, brief description of research interests and contact information of references to Dr. Kirill Martemyanov at kirill@scripps.edu. Both experienced scientists and recent graduates are encouraged to apply. The PI is committed to the career development of trainees.
Principal Investigator Damon Page
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: paged@scripps.edu
URL: http://www.scripps.edu/research/faculty/page
Research Description:

A postdoctoral position is available in the Page laboratory in the Department of Neuroscience to investigate the role of genetic risk factors for autism in the development and function of neuronal cell types involved in behavior, using mouse as a model system. The goal of the project is to understand principles of neural circuit assembly and the influence of autism risk factors on this process at the molecular, structural and behavioral levels. For information about the laboratory, please visit: www.scripps.edu/florida/neuro/page.html

Position Requirements: Requirements: In addition to a PhD in a related discipline, highly motivated candidates must have expertise in genetics, molecular/cell biology, imaging and/or behavioral neuroscience. Interested candidates should send a cover letter, CV and contact details for three references to Damon Page, Ph.D., email: paged@scripps.edu.
Principal Investigator Brock Grill
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: bgrill@scripps.edu
URL: http://www.scripps.edu/grill/
Research Description:

An open postdoctoral position is available in the Grill lab at TSRI, Florida. The candidate's project will focus on understanding the molecular mechanisms of synapse formation and axon termination in C. elegans. The project involves using forward genetic, and RNAi screens to understand the molecular mechanisms of how neurons form synapses and how synapse formation is coordinated with axon extension and termination.

Position Requirements: To be considered, candidates must have a PhD in a related science and previous experience working with C. elegans or another invertebrate model system, such as Drosophila. The successful applicant will have published a minimum of one first author paper in an internationally recognized journal (impact factor greater than 4). The successful applicant, ideally, will have experience performing RNAi or forward genetic screens in C. elegans.

Applicants should submit a cover letter and CV to bgrill@scripps.edu.
Principal Investigator Baoji Xu
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: bxu@scripps.edu
URL: http://www.scripps.edu/florida/neuro/bxu.html
Research Description:

Two postdoctoral positions are available immediately to study local protein synthesis in dendrites and neurotrophin regulation of neural circuit development and function. This research is related to many brain disorders, such as autism, neurodegenerative diseases and obesity. We employ a multidisciplinary approach that includes conditional mouse knockouts, transgenic mice, cell culture, immunohistochemistry, electrophysiology, molecular and biochemical assays (Nat Neurosci 6:736-742, 2003; Cell 134:175-187, 2008; PNAS 108:1669-1674, 2011; Nat Med 18:564-571, 2012). The candidate will work on one of the following three projects: 1) To identify and characterize the secretory pathway for brain-derived neurotrophic factor and other secreted proteins synthesized in neuronal dendrites; 2) To elucidate the molecular mechanism underlying activity-dependent maturation and elimination of synapses; 3) To understand how hypothalamic neural circuits regulate energy balance and glucose homeostasis.

Position Requirements: In addition to a PhD in a related discipline, candidates should be highly motivated and have a strong background in neuroscience, molecular biology, or cell biology. Applicants should submit a CV, a brief statement of research skills, experiences, goals and contact information (e-mail and phone number) for three references to: bxu@scripps.edu.
Principal Investigator Peiqing Sun
Department: Cell and Molecular Biology
Location: La Jolla, CA
Maildrop: MB-41
Email application materials to: pqsun@scripps.edu
URL: http://www.scripps.edu/sun/
Research Description:

We are currently seeking a postdoctoral fellow to work within the laboratory of Dr. Sun. The lab is focused on the dissection of the signal transduction pathways mediating tumor suppressive mechanisms, such as oncogene-induced senescence, using cell culture and animal models. The fellow will be dedicated to characterization of the signaling components related to the p38 MAPK pathway in the context of oncogene-induced senescence, and will be responsible for analyzing the consequence of alterations in these components in cell culture, mouse tumor models and cancer patients.

Position Requirements: Applicants must hold a Ph.D. or equivalent degree with relevant background, and should be highly motivated and enthusiastic about research, and be able to work effectively. Expertise in molecular and cell biology is highly desirable; those with previous experience in cell culture and murine models will be given close consideration. Please send a cover letter discussing your interests in the laboratory as well as your CV and list of 3 individuals as references to pqsun@scripps.edu.
Principal Investigator Peter Kuhn
Department: Cell and Molecular Biology
Location: La Jolla, CA
Maildrop: GAC-1200
Email application materials to: pkuhn@scripps.edu
URL: http://kuhn.scripps.edu/
Research Description:

A Postdoctoral position is available to study the structure and function of protein-protein interactions involved in tumor growth. The position requires a recent Ph.D. in one of the natural sciences relevant to structural biochemistry. Our laboratory is fully equipped for molecular biology, protein chemistry, and protein crystallography. In addition, the laboratory has access to synchrotron beamlines at SSRL and APS.

Position Requirements: The position requires a recent Ph.D. in one of the natural sciences relevant to structural biochemistry. Applicants must be highly motivated and must have demonstrated experience (i.e. relevant publications) with 3D protein structure determination, especially recombinant protein expression (baculovirus preferred), purification, and crystallization.

Please send your CV and a list of at least 3 professional references.
Principal Investigator Joel M. Gottesfeld
Department: Cell and Molecular Biology
Division: 3
Location: La Jolla, CA
Maildrop: MB-119
Email application materials to: joelg@scripps.edu
URL: http://www.scripps.edu/mb/gottesfeld/
Research Description:

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Postdoctoral position for training and research in the neuromuscular disease myotonic dystrophy type 1 is available to an individual with outstanding credentials in cell and molecular biology. Research will focus on the development of a novel therapeutic approach for DM1 based on inhibition of gene transcription with small molecules.

Position Requirements: -Must possess a doctoral degree.
-The successful candidate should have a strong background with excellent publications in cell biology and be familiar with modern techniques in molecular biology, such as PCR, qRT-PCR, DNA gel electrophoresis, western blotting, etc.
-Cell biology experience should include stem cell research, such as iPSC derivation and differentiation, as well as immunofluorescence methods, confocal microscopy, and standard cell culture experience.
-Experience with small animal studies would also be beneficial. Candidate must be in the San Diego area for in-person interview and must be available to start this position shortly.
-The successful candidate will also need to be approved by the funding agency.

Interested individuals should send their CV, and the names/contact information of 3 references to Dr. Joel Gottesfeld at: joelg@scripps.edu.
Principal Investigator Claudio Joazeiro
Department: Cell and Molecular Biology
Division: 3
Location: La Jolla, CA
Maildrop: CB-163
Email application materials to: joazeiro@scripps.edu
Research Description:

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.
Research in the lab investigates the function of E3 ubiquitin ligases in biology and disease (Deshaies & Joazeiro, 2009. Annu Rev Biochem. 78:399-434). The positions available are to elucidate the mechanism of action of the Listerin E3 in a novel pathway of ribosome-associated protein quality control, and/or how defects in Listerin function cause neurodegeneration.
We had previously reported on a new mouse model of ALS/motor neuron disease caused by mutation of Listerin/Ltn1, whose function was unknown at the time (Chu et al. 2009. PNAS 106:2097-103). Listerin is conserved in eukaryotes, so we utilized S. cerevisiae to elucidate its function and mechanism of action, and found that Listerin is associated with ribosomes and mediates quality control of aberrant nascent proteins (Bengtson & Joazeiro 2010. Nature 467:470-3).
Our lab is now undertaking different approaches to continue studying Listerin, including biochemistry, yeast genetics, structural biology, mammalian tissue culture, and gene-disease association studies using ALS patient samples. We are also well positioned to uncover novel molecular mechanisms underlying neurodegeneration by applying the discoveries we make with these approaches to studies on the Listerin mutant mouse model. There are opportunities for studies along any of the above research lines, depending on the background and interests of the applicant.

Position Requirements: A Ph.D. in Biology or in other disciplines of relevance to the project is required. The candidate should have strong conceptual and experimental background in related areas. He/she should be proactive and productive, and have track record of successful project completion.

Interested applicants must send a CV along with a paragraph explaining current and future research interests, and the names and contact information of three professional references.
Principal Investigator Andrew Su
Department: Integrative Structural and Computational Biology
Division: 3
Location: La Jolla, CA
Maildrop: MEM-216
Email application materials to: asu@scripps.edu
URL: http://sulab.org
Research Description:

The Su Lab is currently recruiting for a postdoctoral associate in bioinformatics software development. This position will participate in the design and development of the Gene Wiki, BioGPS, and/or GeneGames.org. All of these applications developed by our lab embrace the principles of community intelligence and crowdsourcing.

Applicants should have a Ph.D. in bioinformatics or biology, and as well as a good foundation in some form of computer programming and statistics. Past experience working with modern genomics data (next gen sequencing, microarrays, proteomics, etc.) is highly desirable.

More information about the lab's interests can be found at http://sulab.org.

Interested individuals should send their CV, a letter describing research interests, and the names/contact information of 3 references to Dr. Andrew Su at: asu@scripps.edu.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
Principal Investigator Raymond Stevens
Department: Integrative Structural and Computational Biology
Location: La Jolla, CA
Maildrop: GAC-1200
Email application materials to: stevens@scripps.edu
URL: http://stevens.scripps.edu/
Research Description:

Membrane Protein Postdoctoral Research Associate position in the area of membrane biochemistry and membrane protein crystallography. Access to novel expression/stabilization technologies, high throughput nanovolume crystallization, automated imaging, and automated beamline synchrotron facilities should greatly accelerate discovery of membrane protein crystallization and structure determination.
More information about the lab and our work can be found at http://stevens.scripps.edu/

Position Requirements: Applicants must have successful experience with membrane proteins from a purification to crystallization or crystallization to structure background.
Please send your CV and a list of at least three professional references.
Principal Investigator Dr. Andrew Su
Department: Integrative Structural and Computational Biology
Division: 3
Location: La Jolla, CA
Maildrop: MEM-216
Email application materials to: asu@scripps.edu
URL: http://sulab.org
Research Description:

The Su Lab is recruiting for multiple postdoctoral associates in bioinformatics and computational biology. These positions will participate in a wide variety of genomics and genetics analyses in close collaboration with world-class experimental researchers at Scripps. Example projects include N-of-1 cancer genomics, osteoarthritis, cystic fibrosis, and microbiomics.

Applicants should have a Ph.D. in bioinformatics or biology, and as well as a good foundation in some form of computer programming and statistics. Past experience working with modern genomics data (next gen sequencing, microarrays, proteomics, etc.) is highly desirable.

More information about the lab's interests can be found at http://sulab.org.

Interested individuals should send their CV, a letter describing research interests, and the names/contact information of 3 references to Dr. Andrew Su at: asu@scripps.edu.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
Principal Investigator Pietro Sanna
Department: Molecular and Cellular Neuroscience
Location: La Jolla, CA
Maildrop: SP-2300
Email application materials to: psanna@scripps.edu
Research Description:

A post-doctoral position is available for a motivated individual to join a dynamic multidisciplinary research team at The Scripps Research Institute to study the neurobiological bases of drug addiction with emphasis on electrophysiology and pharmacology of drug and alcohol abuse. This NIH-funded position offers a competitive pay and benefits package.

Successful candidates will be creative, highly motivated, able to work semi-independently, and have a strong background in electrophysiology including patch whole cell recording. Experience in dynamic clamp, channel biophysics preferred.

Position Requirements: Applicants will have a PhD, MD or equivalent degree. Interested applicants should submit a CV, brief summary of research accomplishments and interests.