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Postdoc Positions

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Principal Investigator Katrin Karbstein
Department: Cancer Biology
Location: Jupiter, FL
Email application materials to: kkarbst@scripps.edu
URL: http://www.scripps.edu/karbstein/Karbstein/Home.html
Research Description:

Postdoctoral Position in Eukaryotic Ribosome Assembly

Research Description: NIH-funded post-doctoral positions are available to study the function of essential proteins required for small ribosomal subunit assembly in yeast, as well as the intersection between 40S ribosome assembly and translational control. A variety of in vitro and in vivo methods, as well as modern systems biology approaches will be used to develop and test models regarding the function of individual assembly factors, providing training opportunities in diverse research techniques. This project is located in Prof. K. Karbstein’s laboratory (http://www.scripps.edu/karbstein/Karbstein/Home.html). Scripps Florida is a dynamic research environment where scientists with both academic and industry experience work collaboratively, ideal for the postdoctoral fellow who is undecided about future career trajectories.

Position Requirements: Applicants with a PhD and published expertise in RNA or protein biochemistry, or yeast genetics and biochemistry will be given close consideration. Funding is in place for 3+ years. Please send a cover letter discussing your interests in the laboratory as well as your CV and list of 3 individuals as references to kkarbst@scripps.edu.
Principal Investigator Tina Izard
Department: Cancer Biology
Location: Jupiter, FL
Email application materials to: cmorrow@scripps.edu
URL: http://www.scripps.edu/florida/cancerbio/izard
Research Description:

Postdoctoral Research Associate positions are immediately available for structure-function studies of cytoskeletal proteins that control signaling downstream of adherens junctions and focal adhesions. Fellows will join an exciting research environment of the Izard laboratory in new state-of-the-art facilities of the Scripps-Florida campus of The Scripps Research Institute (TSRI), which is renowned in the Structural Biology field. The Izard laboratory is recognized as a world leader in the cytoskeleton field.

The position provides an outstanding training program in protein biochemistry and structure, and also in molecular and cellular biology, in a highly dynamic and team-oriented research program. Successful candidates will work in a cutting-edge research environment that tackles this important new arena in cancer and cell biology. The laboratory has outstanding facilities for cell biology, molecular biology, protein expression, purification, and biochemistry, and protein crystallography.

Scripps-Florida provides an incredibly rich scientific environment. Notably, TSRI faculty include an outstanding cadre of senior colleagues, including three Nobel Laureates and about twenty Members of The National Academy of Sciences, including several in crystallography and biophysics. In 2008, Scripps-Florida moved into three new, state-of-the-art research buildings and will expand to eventually house 80 faculty-level investigators. Scripps-Florida has a large cast of outstanding Cores that facilitate basic research and drug development. The unique infrastructure at Scripps-Florida includes the application of unique chemical, genomic, proteomic, informatics, and high-throughput screening and engineering tools for the discovery of novel biomolecules.

Scripps-Florida is a new member of the South East Regional Collaborative Access Team (SER-CAT) that constructed two beam lines at the Advanced Photon Source (APS) at Argonne National Laboratory. The insertion device and bending magnet beam lines are available for all the synchrotron-related data collection needs for the post-doctoral fellows.

Scripps-Florida provides a HighFlux X-ray diffraction system, specifically a Rigaku MicroMax-007 HF, a second-generation true microfocus rotating anode generator. Scripps-Florida also provides an Osmic VariMax optics system and the Proteros Free Mounting System to control the humidity and to optimize diffraction characteristics, including resolution, mosaicity, and anisotropy, as well as reduced X-ray background. Finally, the X-ray laboratory houses the mar345 Image Plate detector.

Palm Beach County is one of the most sought-after communities in the country and offers residents an incomparable lifestyle in a family-friendly community with public playgrounds and parks and access to world-class shopping and unmatched outdoor recreation. It is one of the safest communities in the United States with virtually no crime. The Atlantic Ocean with its 45 miles of spectacular beaches and signature Coconut Palms provides an exclusive getaway in a warm, sunny climate throughout most of the year. There are a number of exquisite art galleries as well as arts and crafts festivals. This golfer’s paradise is also home of the Professional Golfers Association of America (PGA).

Position Requirements: Applicants must have a Ph.D. degree and experience in protein crystallography. Please send CV, a summary of research experience and interests, and names, addresses, e-mail and telephone numbers of 3 references to:

Dr. T. Izard (cmorrow@scripps.edu)
Associate Professor with Tenure
Director, Macromolecular Crystallography Scripps-Florida
Cell Adhesion Laboratory
Department of Cancer Biology
The Scripps Research Institute
Jupiter, FL 33458
Principal Investigator Matthew Pipkin
Department: Cancer Biology
Location: Jupiter, FL
Email application materials to: mpipkin@scripps.edu
URL: http://www.scripps.edu/research/cancer-biology/index.html
Research Description:

The mechanics of nucleosome positioning:
A postdoctoral position within the Department of Cancer Biology is available to study the transcriptional mechanics underlying effector and memory CD8+ T cell differentiation. The candidate’s goals will be to clarify how transcription factor expression levels combined with their affinities for cognate binding sites in DNA control nucleosome positioning and transcription in vivo. The lab has developed and applied novel approaches that integrate bacterial artificial chromosome (BAC) technology and next generation sequencing to map nucleosomes in vivo at unprecedented resolution. A number of genetic tools and approaches are available in the lab to alter expression of essential CD8 T cell specific transcription factors in vitro and in vivo, such as conditional knockout mice, retrovirally expressed cDNAs and whole-genome retroviral shRNA-miR libraries, to examine at the genome-scale how these factors control nucleosome positions and CTL differentiation.

Position Requirements: The ideal candidate will have a Ph.D. in a biological, chemical, or physical science, a quantitative mindset, and a committed desire to learning and applying classical and cutting-edge molecular and biochemical approaches to address the regulation of chromatin and transcription in the immune system.

Interested applicants should submit a CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: mpipkin@scripps.edu.
Principal Investigator Matthew Pipkin
Department: Cancer Biology
Location: Jupiter, FL
Email application materials to: mpipkin@scripps.edu
URL: http://www.scripps.edu/research/cancer-biology/index.html
Research Description:

The transcriptional circuitry of CTL differentiation:
A postdoctoral position within the Department of Cancer Biology is available to study the genetic, molecular and cellular basis of effector and memory CD8+ cytotoxic T lymphocyte (CTL) differentiation. The candidate will develop new, and use available, strains of reporter and gene deficient mice to examine the regulation of effector and memory CTL development in response to model infections and tumors. These approaches will be combined with custom retroviral shRNA-miR libraries targeting transcriptional regulators, in the context of infectious models in vivo and simplified in vitro differentiation systems, to discover and dissect the transcriptional circuitry of CTL differentiation. To clarify important questions underlying cell-differentiation, the candidate will apply sophisticated genetic and molecular approaches such as chromosome transfer, BAC recombineering and transgenesis, and next generation sequencing of RNA and DNA derived libraries.

Position Requirements: The ideal candidate will have a Ph.D. in immunology, a strong background in genetics, and extensive experience with flow cytometry and or fluorescent microscopy. In addition, experience with mice and a committed desire to learn and apply classical and cutting-edge molecular biology approaches are strongly desired.

Interested applicants should submit a CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: mpipkin@scripps.edu.
Principal Investigator Dr. Min Guo
Department: Cancer Biology
Location: Jupiter, FL
Email application materials to: guomin@scripps.edu
URL: http://www.scripps.edu/guo/
Research Description:

Immunology Postdoctoral Fellowship Position @ Scripps Laboratories for tRNA Synthetase Research (SLTSR)

Research Description: The fellow will be involved in projects focused on the development of human aminoacyl tRNA synthetase related therapy for asthma and cancer research.


Position Requirements: Position Requirements: The ideal candidate will have a Ph.D. in a relevant scientific discipline. Proficiency in molecular biology, immunology, mice model is required. Additional experience in cell imaging, asthma, and bioengineering will be plus. Applicants must be highly motivated with a strong interest in Basic Research. Additional information can be found at:
http://www.scripps.edu/guo/

Interested applicants should submit a CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: guomin@scripps.edu.
The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.



Principal Investigator Kerri A. Mowen
Department: Chemical Physiology
Division: 3
Location: La Jolla, CA
Maildrop: IMM-11
Email application materials to: kmowen@scripps.edu
URL: http://www.scripps.edu/mowen/
Research Description:

A postdoctoral position for an enthusiastic, motivated, and independent individual is available in our lab. Expertise in molecular biology, protein purification, biochemistry, and immunobiology is highly advantageous. Organizational skills are a must.

Interested candidates should submit their CV and a list of at least 3 professional references to kmowen@scripps.edu.

Position Requirements: Ph.D. in molecular biology, immunology, biochemistry, or cell biology is required. Good communication and organizational skills are a must.

A pending doctoral degree may be considered with approval of the Principal Investigator.
Principal Investigator Brian Paegel
Department: Chemistry
Location: Jupiter, FL
Email application materials to: briandna@scripps.edu
Research Description:

A postdoctoral fellowship is available in synthetic biology, cell-based screening, and lipid bilayer vesicle assembly in the laboratory of Prof. Brian Paegel at The Scripps Research Institute in Jupiter, FL.

Scripps Florida is a dynamic research environment where scientists with both academic and industry experience work collaboratively, ideal for the postdoctoral fellow who is undecided about future career trajectories.

Position Requirements: To be considered, applicants must have a doctoral degree and published expertise in a
subset of fields including microfluidics, liposome/GUV synthesis and analysis, and membrane protein biochemistry.

If you are interested in joining our highly interdisciplinary team, please submit your cover letter, CV and a sample publication to Dr. Brian Paegel, briandna@scripps.edu.
Principal Investigator Kate Carroll
Department: Chemistry
Location: Jupiter, FL
Email application materials to:
URL: http://www.scripps.edu/research/faculty/carroll
Research Description:

The Carroll lab in the Department of Chemistry at Scripps, Florida currently has NIH-funded postdoctoral positions available in the areas of Cellular and Molecular Biology, Chemical Biology and Synthetic Chemistry.

Position Requirements: Candidates should possess a PhD in a related scientific discipline.

Postdoctoral candidates should send an inquiry with their CV and have three references send letters of recommendation to kcarroll@scrippps.edu.

In the application / cover letter, please address the following: (1) What are your scientific goals and interests, and how might your graduate research background be leveraged to create synergy with the strengths of our laboratory? (2) What, if any, are your plans for obtaining postdoctoral fellowship funding? (3) What are your long-term career plans as of today? Complete applications with published experience in the above focus areas will be given priority.
Principal Investigator Dr. Matthew Disney
Department: Chemistry
Location: Jupiter, FL
Email application materials to: jdisney@scripps.edu
URL: http://www.scripps.edu/disney/index.html
Research Description:

The Department of Chemistry at The Scripps Research Institute in Jupiter, FL is seeking highly motivated postdoctoral associates with strong backgrounds in bioorganic chemistry (nucleic acids) or RNA biochemistry / biophysics to join our team.

KEY RESPONSIBILITIES:
• Design and execute experiments to investigate RNA-small molecule recognition events
• Design / identify novel small molecules that bind RNA
• Design and execute cell-based assays to investigate bioactivity of small molecules
• Preparation of manuscripts
• Intellectual engagement and knowledge of scientific literature
• Work in an interdisciplinary environment and gain experience
• Documentation / maintenance of laboratory notebook

Position Requirements: REQUIRED EXPERIENCE:
• Strong background in nucleic acids biochemistry
• Experience in small molecule drug screening
• Highly self-motivated with excellent problem solving and analytical skills, and able to work systematically
• Excellent communication and organizational skills and ability to work with others

Candidates should have a Ph.D. in chemistry, biochemistry, biology, or a closely related field and proven experience in biochemical, molecular, and cellular techniques. The successful candidate will be fluent in English, have good interpersonal and communication skills, and be able to work independently and within a team.

Please send a cover letter (summarizing your experience and expertise, how you will apply that experience, and your area of scientific interest), your CV, and a list of references to:

Professor Matthew Disney
Email: jdisney@scripps.edu
The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

Principal Investigator Eric Zorrilla
Department: Committee on the Neurobiology of Addictive Disorders
Location: La Jolla, CA
Maildrop: SP30-2400
Email application materials to: ezorrilla@scripps.edu
URL: http://www.scripps.edu/zorrilla
Research Description:

A post-doctoral position is available for a highly motivated individual to join the Zorrilla lab at The Scripps Research Institute to study the neurobiology of reward and stress circuits relevant to the pathophysiology and treatment of emotional disorders, compulsive eating, obesity, and alcoholism. Competitive candidates for this NIH-funded position will be highly creative, motivated and self-sufficient.

For more details on our areas of interest, please see the lab webpage at www.scripps.edu/zorrilla.

Position Requirements: Applicants will have a PhD, MD or equivalent degree with strong conceptual and experimental background in molecular biology, neuroscience, pharmacology, endocrinology, or a related discipline. Experience in optogenetics or epigenetics is preferred. Qualified applicants should submit a CV, summary of research accomplishments and interests, and names of three references to Dr. Eric Zorrilla at ezorrilla@scripps.edu.
Principal Investigator Olivier George
Department: Committee on the Neurobiology of Addictive Disorders
Division: 7
Location: La Jolla, CA
Maildrop: SP-2400
Email application materials to: ogeorge@scripps.edu
URL: http://www.scripps.edu/george/
Research Description:

The George lab (www.oliviergeorge.com) is seeking applications for postdoctoral traineeships. The successful applicant will receive training under support from a Collaborative Research on Addiction at NIH (CRAN) supplement to our NIH/NIAAA Institutional Training Grant (T32 AA007456) which has been training young scientists in the field of substance abuse research for over 25 years.
The Program is directed by Dr. Loren H. Parsons with the support of a Program Faculty which includes Drs. Candice Contet, Cindy Ehlers, Olivier George, Chitra Mandyam, Barbara Mason, Marisa Roberto, Pietro Sanna, Paul Schweitzer, Michael Taffe, Friedbert Weiss and Eric Zorrilla. This solicitation seeks applicants who have an interest in the interactive effects of alcohol and other abused substances or who seek to investigate common mechanisms that may contribute to polysubstance abuse. Due to the established epidemiology of alcohol-drug combinations there will be a priority on interactions with nicotine (Ehlers, George, Mandyam, Mason, Parsons, Roberto and Wall), cannabinoids (Ehlers, Mason, Parsons, Roberto, Sanna,Schweitzer,Taffe) and opioids (Contet, George, Roberto, Roberts, Sanna, Schweitzer, Taffe, Weiss). The collective research interests of the Program Faculty provide an integrated and comprehensive research program on various facets of substance use disorders.
This includes projects focused on 1) molecular biology, genetic manipulation and both preclinical and clinical characterization of alcohol and drug use across distinct populations; 2) characterization of neural mechanisms of reward, dependence, withdrawal and relapse using electrophysiology, in
vivo neurochemistry, pharmacogenetics, optogenetics and neural plasticity; 3) behavioral analyses using animal models of binge-like drug consumption, escalation of drug intake which models compulsive consumption, negative reinforcement of drug taking during dependence, dysregulated stress responsivity and affect control during protracted withdrawal, impaired cognitive function (e.g. impulsivity, attentional capacity, cognitive flexibility, conditioned fear) and reinstatement of extinguished
drug-seeking behavior; 4) clinical studies of risk factors, biomarkers and trajectories of drug use initiation, abuse, dependence, remission and relapse; 5)coordinated clinical and preclinical evaluations of potential medications for alcohol and drug dependence.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Applicants should have a recent doctoral degree in a relevant field and a strong interest in substance abuse research. US citizenship or Permanent Resident status is required.
An ability to think critically and creatively, along with strong writing and communication skills is essential.Experience in optogenetics, pharmacogenetics and animal model of alcohol and drug addiction is recommended but not required.

Qualified applicants should submit a CV, summary of research accomplishments and interests, and names of three references to Dr. Olivier George at ogeorge@scripps.edu.
Principal Investigator J. Lindsay Whitton
Department: Immunology and Microbial Science
Division: 3
Location: La Jolla, CA
Maildrop: SP-2110
Email application materials to: lwhitton@scripps.edu
URL: http://www.scripps.edu/research/faculty/whitton
Research Description:

Postdoctoral position available June 1, 2015, to study viral pathogenesis. Applicant should be trained in molecular virology / immunology. Salary will followNIH guidelines. Expected duration: two years.
Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator. Prior experience with mouse models is preferred. Please email application to lwhitton@scripps.edu.
Principal Investigator Nathalie C Franc
Department: Immunology and Microbial Science
Division: 3
Location: La Jolla, CA
Maildrop: IMM-116
Email application materials to: nfranc@scripps.edu
URL: http://www.scripps.edu/franc/
Research Description:

A Post-Doctoral Research Associate position is available to work in the Franc lab to study the molecular mechanisms of phagocytosis using the fruitfly Drosophila melanogaster as a model system. Our laboratory uses genetics, molecular and cell biology techniques, as well as confocal microscopy. Previous experience with Leica confocal microscopy would be a plus, but is not absolutely necessary.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

APPLY with a cover letter explaining why you are interested in this position, include your full CV, and have three references. Send letters of recommendation to nfranc@scripps.edu.

Position Requirements: Candidates must have recently completed a Ph.D. in a biology field with experience working with Drosophila and classical molecular and cell biology techniques routinely used with this model system.
Principal Investigator Ann Feeney
Department: Immunology and Microbial Science
Division: 3
Location: La Jolla, CA
Maildrop: IMM-22
Email application materials to: feeney@scripps.edu
URL: http://www.scripps.edu/ims/feeney/
Research Description:

A postdoctoral position is available for a highly motivated candidate with strong molecular biology skills for studies on immunoglobulin repertoire. Our lab studies the epigenetic, genetic and transcriptional control of V(D)J rearrangement, B cell repertoire formation, and B cell differentiation. Utilizing ChIP-seq, RNA-seq, and chromosome conformation capture (3C) approaches, we study the 3-dimensional changes which take place in the immunoglobulin loci during V(D)J rearrangement, and the transcription factors which regulate these changes. Using deep sequencing, we study how these changes in structure affect the composition of the resulting antibody repertoire. We are also analyzing single cell transcriptional heterogeneity within pro-B cell subsets. The ideal candidate will have some computational expertise as well as strong molecular biology skills.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Candidates with a Ph.D. and/or M.D. and with a strong background in molecular biology are encouraged to apply. Ideal candidates will also have skills in computational biology. Interested candidates should submit their CV and the names and contact information for at least three references to feeney@scripps.edu.
Principal Investigator Kristian Andersen
Department: Immunology and Microbial Science
Division: 3
Location: La Jolla, CA
Maildrop: SGM-300A
Email application materials to: jobs@andersen-lab.com
URL: http://andersen-lab.com/
Research Description:

The Andersen lab is working on diverse projects studying the interaction and co-evolution between viruses and the human immune system using high-throughput technologies, such as next-generation sequencing. We are also developing technologies and computational tools to use next-generation sequencing as a novel technology for unbiased pathogen discovery. Our research is primarily focused on Ebola and Lassa virus and we use a combination of fieldwork in West Africa, technology development, and computational biology to investigate these viruses.

Tasks will include:
• Develop novel data analysis strategies, write algorithms, and deploy computational tools for the exploration of large sequencing-based data sets.
• Perform independent research exploring the utility and applications of next-generation sequencing in a clinical setting.
• Conceive, implement and test statistical models; work with wet-lab researchers to translate these models into testable experiments; analyze the data produced from these experiments

*Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: The Scripps Research Institute is currently seeking a computational postdoc for the Andersen Lab working in the Department of Immunology and Microbial Sciences and Scripps Translational Science Institute. The successful candidate will join an interdisciplinary team of scientists, biologists, clinicians and computational scientists to apply computational, statistical and machine learning methods to advance the state of the art in computational genomics. We are looking for a dedicated individual who is interested in developing novel computational tools and pipelines that will help transform medicine with a direct impact on human health.

Requirements include:
• Ph.D. in bioinformatics, computational biology, computer science, computer engineering, mathematics, statistics, physics, or similar is required.
• Experience with computational data analysis using ‘Big Data’, including knowledge of statistical concepts is highly desired.
• Programming skills in scripting languages such as Python/Perl, and analysis tools like MATLAB/R required. Experience with cluster computing, parallelization, and software engineering preferred.
• Familiarity with version control systems such as git or subversion preferred but not required.
• Experience with next-generation sequencing datasets desired, but not required.
• Strong interpersonal skills and the ability to work with and mentor junior scientists and students.

Interested candidates should submit their CV and the names and contact information for at least three references to jobs@andersen-lab.com.
Principal Investigator Philippe Gallay
Department: Immunology and Microbial Science
Division: 3
Location: La Jolla, CA
Maildrop: IMM-9
Email application materials to: gallay@scripps.edu
URL: http://www.scripps.edu/gallay/
Research Description:

The position will be involved in the investigation of mechanisms of hepatitis B virus (HBV) replication both in vitro and in vivo as well as to identify mechanisms of action of new anti-HBV agents.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator. Strong research experience in virology and cell culture highly preferred.

Interested candidates should submit their CV and the names and contact information for at least three references to gallay@scripps.edu.
Principal Investigator Philippe Gallay
Department: Immunology and Microbial Science
Division: 3
Location: La Jolla, CA
Maildrop: IMM-9
Email application materials to: gallay@scripps.edu
URL: http://www.scripps.edu/gallay/
Research Description:

This positions will be responsible for conducting both in vitro and in vivo constant and extended drug delivery studies in humanized mice for HIV-1 infection. Similar drug delivery implant approaches will be conducted for additional viral infections such as Dengue infection.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Interested candidates should submit their CV and the names and contact information for at least three references to gallay@scripps.edu.
Principal Investigator Choe, Farzan, Lasmezas, Tellinghuisen, Valente
Department: Infectious Diseases
Location: Jupiter, FL
Email application materials to: IDsearch@scripps.edu
URL: http://www.scripps.edu/florida/research/infectious-diseases/index.html
Research Description:

Postdoctoral fellowships in Microbiology and Infectious Diseases
The Scripps Research Institute, Scripps Florida

The Department of Infectious Diseases at The Scripps Research Institute in Jupiter, Florida is hiring new post-doctoral fellows in the following areas:

Flaviviruses and emerging pathogens (Dr. Hyeryun Choe)
HIV-1 antibody evolution and vaccine development (Dr. Michael Farzan)
Neurodegenerative diseases of prions and other transmissible proteins (Dr. Corinne Lasmezas)
Hepatitis C replication and host interactions (Dr. Tim Tellinghuisen)
HIV-1 latency and the cure (Dr. Susana Valente)

The Department of Infectious Diseases is part of the highly collaborative research environment on the beautiful Florida campus, with exceptional resources in proteomics, genomics, drug discovery, and medicinal chemistry. Qualified candidates may be eligible for a two-year Institute Fellowship. Send CV and a cover letter indicating primary area of research interest by September 10th to IDsearch@scripps.edu.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
Principal Investigator Anutosh Chakraborty
Department: Metabolism and Aging
Location: Jupiter, FL
Email application materials to: ariggs@scripps.edu
Research Description:

Postdoctoral/Research Associate position available in the area of biochemistry of obesity and diabetes.”

A postdoctoral position is available in the Chakraborty laboratory at The Scripps Research Institute for a NIH(RO1)-funded project. The laboratory focuses on unraveling the molecular mechanisms that regulate cellular energy metabolism especially in the adipose tissue. Using white and brown adipose tissue depots and adipocytes isolated from healthy and diet induced obese mice, alterations in cellular pathways are determined. The goal is to identify novel proteins which can be targeted in metabolic diseases such as obesity, diabetes and cardiovascular diseases.

In this regard, inositol hexakisphosphate kinase-1 (IP6K1), an enzyme in the inositol pyrophosphate biosynthetic pathway, was discovered as a key player in energy homeostasis. Studies in whole body (Chakraborty et al. Cell, 2010) and adipose tissue-specific IP6K1 knockout (unpublished work in the laboratory) mice reveal that targeting IP6K1 in the adipose tissue decelerates weight gain and improves metabolic parameters in high fat-fed mice. Current research is focused to decipher the molecular mechanisms by which IP6K1 promotes obesity and insulin resistance. Furthermore, impacts of pharmacologic inhibition of this class of enzymes on metabolic parameters of obese and diabetic mice are also being explored. These studies are expected to have immediate application in ameliorating metabolic diseases.

Position Requirements: Interested candidates with a recently earned Ph.D. are encouraged to apply. A track record of excellent first author publication during PhD training is essential. Strong background in biochemistry and cell/molecular biology is required. Extensive experience in the area of adipose tissue metabolism and survival is desirable. To be considered, please send a CV, including a summary of research experience and interests, along with contact information for 3 references to ariggs@scripps.edu.

TSRI embraces diversity & recognizes it as being a key to our success. EOE/M/F/V/D
Principal Investigator Dr. Matthew Gill
Department: Metabolism and Aging
Location: Jupiter, FL
Email application materials to: mgill@scripps.edu
URL: https://www.scripps.edu
Research Description:

A post-doctoral position is available in the laboratory of Dr Matthew Gill in the Department of Metabolism & Aging at The Scripps Research Institute, Scripps Florida. Work in the lab is focused on characterizing signaling pathways in the nematode C. elegans that are involved in development and lifespan determination. This is being achieved by using an interdisciplinary approach combining genetic, genomic, biochemical and analytical chemistry approaches. The broader significance of this research is to further define the role of these signaling pathways in the etiology of aging and age-related disease and identify new targets for therapeutic intervention.

Position Requirements: Requirements: The position requires a PhD in a related scientific discipline with experience and publications demonstrating expertise in any of the following areas: genetics, molecular biology, protein expression & purification, lipid analysis or cell culture. Experience working with C. elegans and / or a background in aging research would be preferred but is not required.
To be considered, please send a cover letter describing your research interests, your CV, copies of representative publications, and a list of three individuals that can serve as references to Dr. Matthew Gill, mgill@scripps.edu.

For more information, visit www.scripps.edu. TSRI embraces diversity & recognizes it as being a key to our success. EOE/M/F/V/D
Principal Investigator Dr. Paul Robbins
Department: Metabolism and Aging
Location: Jupiter, FL
Email application materials to: ariggs@scripps.edu
Research Description:

A Postdoctoral Research Associate position is immediately available in the laboratory of Paul Robbins. This position is to explore the role of NF-kB in driving cellular senescence, stem cell dysfunction and age-related pathology and to develop novel inhibitors of IKK/NF-kB. The postdoctoral fellow will join an exciting research environment in the Department of Metabolism and Aging in the new state-of-the-art facilities of the Scripps Florida campus of The Scripps Research Institute. The position offers exceptional training in stem cell biology, microvesicles, drug screening, age-related degenerative diseases, mouse models of aging, signal transduction, cellular senescence and molecular therapeutics.

Position Requirements: Applicants must have a Ph.D. degree, experience in molecular and cellular biology and interest in working with murine models of age-related disease. Special attention will be given to applicants with significant experience in stem cells, microvesicles, mammalian cell culture, drug screening, IKK/NF-B signaling, metabolism and/or mitochondrial biology. Please send a CV, including a summary of research experience and interests, along with contact information for 3 references to ariggs@scripps.edu

Principal Investigator Dr. Paul Robbins
Department: Metabolism and Aging
Location: Jupiter, FL
Email application materials to: ariggs@scripps.edu
Research Description:

A Postdoctoral Research Associate position is immediately available in the laboratory of Paul Robbins. This position is to work on characterizing the factor(s) secreted by adult stem cells from young, but not old mice that can extend lifespan and health span in a mouse model of accelerated aging. The postdoctoral fellow will join an exciting research environment in the Department of Metabolism and Aging in the new state-of-the-art facilities of the Scripps Florida campus of The Scripps Research Institute. The position offers exceptional training in stem cell biology, microvesicles, drug screening, age-related degenerative diseases, mouse models of aging, signal transduction, cellular senescence and molecular therapeutics.



Position Requirements: Applicants must have a Ph.D. degree, experience in molecular and cellular biology and interest in working with murine models of age-related disease. Special attention will be given to applicants with significant experience in stem cells, microvesicles, mammalian cell culture, drug screening, metabolism and/or mitochondrial biology. Please send a CV, including a summary of research experience and interests, along with contact information for 3 references to ariggs@scripps.edu.
Principal Investigator Sandra Encalada
Department: Molecular and Experimental Medicine
Location: La Jolla, CA
Maildrop: MEM-215
Email application materials to: encalada@scripps.edu
URL: http://www.scripps.edu/encalada/
Research Description:

A postdoctoral position is available in the Encalada Laboratory at The Scripps Research Institute in La Jolla, California, USA, in the areas of neurodegeneration, aging, and intracellular transport. Our lab is interested in characterizing the mechanisms of regulation of molecular motor-driven transport in neurons and the role that defective transport plays in neurodegeneration and aging, with an emphasis on prion, Alzheimer’s and other aggregation-associated degenerative diseases. We use a combination of cell biology, genetics, biochemistry, and high-resolution quantitative microscopy in mammalian neurons and in C. elegans to address these research areas, and possible projects include characterization of model organism models of neurodegenerative diseases.

Position Requirements: You are about to complete your PhD or have completed your PhD within the last year in cell biology, genetics, neurobiology, molecular biology, biophysics, or related field.
Preferred candidates are highly motivated, independent, with outstanding written and oral communication skills, and ideally with peer-reviewed publications. Plus research experience with C. elegans and/or cell culture, and with light microscopy is preferred but not required.

Interested candidates please send a CV with a list of publications, a brief statement of your previous research expertise, future interests, and the contact information of three references to Sandra Encalada at encalada@scripps.edu. For more information also please consult our website at http://www.scripps.edu/encalada/encalada/HOME.html
Principal Investigator Dan Salomon
Department: Molecular and Experimental Medicine
Division: 3
Location: La Jolla, CA
Maildrop: MEM-241
Email application materials to: dsalomon@scripps.edu
URL: http://www.scripps.edu/salomon/
Research Description:

During this appointment, you will be involved in a large project studying the regulation of cellular immunity in humans with specific relevance to understanding transplantation immunity and development of biomarkers for clinical translation that also extend our understanding of immunity. The work is highly technical, molecular biology and biochemistry. We are studying a genomic space comprised of DNA sequence, epigenetic changes, transcriptional regulation, microRNA regulation, alternative splicing, other forms of non-coding RNA regulation and the role of RNA binding proteins. Studies include DNA microarrays, ChIP-SEQ, RNA-SEQ, miRNA-SEQ, biochemistry ofRNA binding proteins and biostatistical analysis of functional genomics. The scientific emphasis is on the importance of this multidimensional complexity in understanding cellular immunity but that is balanced by the need to select the highest value candidate pathways for focused, mechanistic validations required to advance the knowledge in the field.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Must possess a doctoral degree in a related field. A pending doctoral degree may be considered with approval of the Principal Investigator.

Interested applicants should submit a CV, brief summary of research accomplishments and interests, and three (3) professional references to dsalomon@scripps.edu.
Principal Investigator Kevin Morris
Department: Molecular and Experimental Medicine
Division: 3
Location: La Jolla, CA
Maildrop: MEM-125
Email application materials to: kmorris@scripps.edu
URL: http://www.scripps.edu/morris/
Research Description:

A post-doctoral position is available immediately for a highly-motivated individual to join our efforts in developing novel experimental gene-based therapies for HIV. We are seeking applicants who are highly motivated, passionate, and innovative, and can work both independently and in a team environment. The project involves applying the latest advances in molecular and cell biology to inhibit or reactivate viral infection in cell culture and animal models of infection. We aim to focus on completely eradicating HIV, “cure research”, using novel experimental therapies such as conditional replicating lentiviral vectors, genome engineering/remodeling tools (eg. CRISPR/Cas9), and NGS (ChIP-Seq, RIP-Seq). This is an NIH-funded position offers a competitive pay and benefits package.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: PhD, MD, or MD/PhD with a strong background in molecular and cellular biology with expertise in one or more of the following areas: RNA biology/biochemistry, HIV, vectors (AAV, lentiviral vectors), genome engineering tools (ZFNs, TALENs, CRISPR/Cas9), epigenetic techniques (eg. ChIP, Bisulfite sequencing), NGS and/or bioinformatics/coding. Candidates with 0-3 years of post-doctoral training will be considered.

Interested applicants should submit a CV, brief summary of research accomplishments and interests, and three (3) professional references to kmorris@scripps.edu.
Principal Investigator Douglas Kojetin
Department: Molecular Therapeutics
Location: Jupiter, FL
Email application materials to: dkojetin@scripps.edu
URL: http://www.scripps.edu/research/faculty/kojetin
Research Description:

Postdoctoral Position in Nuclear Receptor Structural Pharmacology
Our lab focuses on structure-function relationships and the role of protein dynamics in activation of nuclear receptors by small molecule ligands, including natural ligands and synthetic ligands (drugs).
We are seeking motivated postdoctoral candidates with expertise in one or both of the following areas:
- structural biology, x-ray crystallography (preferred) or NMR spectroscopy
- molecular/cell biology or pharmacology

Position Requirements: Ph.D. in a relevant scientific discipline with expertise in structural biology and/or molecular/cell biology or pharmacology. Funding is in place through an imminent 5 year NIH grant award. For consideration, send a cover letter stating your research and career interests, a CV and contact information for 3 references to dkojetin@scripps.edu.
Principal Investigator Philip LoGrasso
Department: Molecular Therapeutics
Location: Jupiter, FL
Email application materials to: kobrien@scripps.edu
URL: http://www.scripps.edu/research/faculty/lograsso
Research Description:

The Department of Molecular Therapeutics at The Scripps Research Institute, Scripps Florida, is seeking a post doctoral candidate with experience in neurobiology, cell biology, molecular biology, and biochemistry. The project is centered on oxidative stress and neurodegeneration both in vitro and in vivo and is trying to delineate aspects of both mitochondrial dysfunction and ER stress. Our lab has a significant focus on kinases, with a particular interest in JNK, LRRK2, and SGK-1. The candidate will be responsible for investigating the role of mitochondrial JNK signaling, how LRRK2 interacts with the JNK pathway, and how SGK-1 may affect LRRK2.

Interested applicants are encouraged to submit a curriculum vitae and the names and contact information for three references to: Dr. Philip LoGrasso, TSRI, kobrien@scripps.edu.

Position Requirements: The ideal candidate will have a Ph.D. in Neuroscience, Cell Biology, or Biochemistry or a related field and have demonstrated expertise in all of the areas listed above. Detailed knowledge of mitochondrial functional assays, immunocytochemistry, isolation of primary neurons, and apoptotic and cytotoxicity assays is required. Experience in stereotactic surgery and confocal microscopy is a plus.
Principal Investigator Scott B. Hansen
Department: Molecular Therapeutics
Location: Jupiter, FL
Email application materials to: shansen@scripps.edu
URL: http://www.scripps.edu/research/faculty/hansen
Research Description:

Postdoctoral Position in Ion Channels Electrophysiology and Mechanosensation
The Scripps Research Institute, Florida

Postdoctoral candidates with interests in Molecular Neuroscience, Drug Discovery, Molecular Pharmacology, or Cell Signaling are encouraged to apply for a position at the Scripps Research Institute in the laboratory of Dr. Scott B. Hansen.

Scripps is a world-class biomedical research institute with a new state-of-the-art campus adjacent to the Max Planck Institute in Jupiter, Florida. Successful candidates will join a vibrant scientific community of drug discovery and neuroscience while enjoying the pristine beaches and desirable weather of Florida.

The position will focus on mechano sensitive ion channels and the molecular sensor for mechanical force. A generous 5-year NIH New Innovator Award funds this project. Successful applicants will make fundamental discoveries in mechanosensation and develop cutting edge techniques in molecular neuroscience.

Position Requirements: Applicants should have completed a Ph.D. in a biological science, be motivated, and have demonstrated prior laboratory experience with protein biochemistry. Experience with electrophysiology is most desirable followed by cell signaling, molecular biology, lipids, or pharmacology.
Principal Investigator Ron Davis
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: rdavis@scripps.edu
URL: http://www.scripps.edu/research/faculty/davis
Research Description:

Currently seeking Postdoctoral Research Associates who will work on projects involving the molecular and cellular biology of memory formation in Drosophila and the mouse using genetic, molecular, cellular, anatomical and behavioral approaches. In addition, selected individuals may perform translational research on mood disorders and Alzheimer's disease.

Position Requirements: PhD in a relevant scientific discipline and experience with research projects that employ diverse techniques and address questions that range from the molecular to the behavioral is required.

To be considered, submit Curriculum Vitae and complete contact information for at least three professional references as a single PDF file, to rdavis@scripps.edu.
Principal Investigator Kirill Martemyanov
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: kirill@scripps.edu
URL: http://www.scripps.edu/martemyanov
Research Description:

Molecular and Cellular Neurobiology of GPCR Systems

An NIH funded postdoctoral position is available within the Jupiter, FL campus to study molecular, cellular and behavioral aspects of neuronal signaling. We are looking for an energetic colleague with keen interest in science and solid background in the areas of physiology, molecular and cell biology.

The laboratory is interested in delineating mechanisms by which GPCR pathways control reward behavior, vision and provide neural control of the cardiac function. It is expected that the project will contribute to our understanding of the neuropsychiatric diseases, drug addiction and vision loss while focusing on the discovery of the fundamental neurobiological principles. Multidisciplinary approach integrating behavioral characterization of genetic mouse models with live cell imaging, biochemical analysis of signaling reactions and discovery of novel interactions by mass-spectrometry assisted proteomics is envisioned. For details visit the website of the laboratory at http://www.scripps.edu/martemyanov.

Position Requirements: Requirements: PhD in a related scientific discipline and experience with electrophysiological approaches and/or genetic mouse models for investigation of cardiovascular function is required. An energetic colleague with keen interest in science and solid background in the areas of physiology, molecular and cell biology is strongly desired.

To be considered, please send CV, brief description of research interests and contact information of references to Dr. Kirill Martemyanov at kirill@scripps.edu. Both experienced scientists and recent graduates are encouraged to apply. The PI is committed to the career development of trainees.
Principal Investigator Brock Grill
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: bgrill@scripps.edu
URL: http://www.scripps.edu/grill/
Research Description:

An open postdoctoral position is available in the Grill lab at TSRI, Florida. The candidate's project will focus on understanding the molecular mechanisms of synapse formation and axon termination in C. elegans. The project involves using forward genetic, and RNAi screens to understand the molecular mechanisms of how neurons form synapses and how synapse formation is coordinated with axon extension and termination.

Position Requirements: To be considered, candidates must have a PhD in a related science and previous experience working with C. elegans or another invertebrate model system, such as Drosophila. The successful applicant will have published a minimum of one first author paper in an internationally recognized journal (impact factor greater than 4). The successful applicant, ideally, will have experience performing RNAi or forward genetic screens in C. elegans.

Applicants should submit a cover letter and CV to bgrill@scripps.edu.
Principal Investigator Baoji Xu
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: bxu@scripps.edu
URL: http://www.scripps.edu/florida/neuro/bxu.html
Research Description:

Postdoctoral positions are available to work on projects investigating synaptic plasticity, control of synaptic protein synthesis, and central control of energy balance in mice using genetic, cellular, molecular, viral, histological, physiological, and behavioral approaches. These research projects are related to many diseases, such as autism spectrum disorders, depression, obesity, and diabetes. The successful candidates also have opportunities to work on translational projects related to Huntington’s disease and Alzheimer’s disease.

Position Requirements: In addition to a PhD in a related discipline, candidates should be highly motivated and have a strong record of productivity. Those with a strong background in electrophysiology or medicinal chemistry are particularly encouraged to apply. Interested candidates should send a cover letter, curriculum vitae and contact information for three references to: bxu@scripps.edu.
Principal Investigator Dr. Ron Davis
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: rdavis@scripps.edu
URL: http://www.scripps.edu/research/faculty/davis
Research Description:

Currently seeking Postdoctoral Research Associates who will work on projects involving small molecule screening against molecular or phenotypic targets for the purpose of identifying new probes and lead compounds for neuroprotection and cognitive enhancement.

Position Requirements: PhD in a relevant scientific discipline and experience with research projects that employ diverse techniques and address questions that range from the molecular to the behavioral is required.

To be considered, submit Curriculum Vitae and complete contact information for at least three professional references as a single PDF file, to rdavis@scripps.edu.

Principal Investigator Dr. Sathya Puthanveettil
Department: Neuroscience
Location: Jupiter, FL
Email application materials to: sputhanv@scripps.edu
URL: www.scripps.edu/puthanveettil
Research Description:

A postdoctoral position is immediately available for a motivated individual to join a dynamic multidisciplinary research team to study synaptic plasticity and memory storage using marine snail Aplysia californica in the Puthanveettil Laboratory at The Scripps Research Institute-Scripps Florida (www.scripps.edu/puthanveettil). Examples of ongoing research using Aplysia can be found in the following publications: Choi et al., PLOS One (2014), 9(7):e103004; Akhmedov et al., PLOS One (2013), 8(12):e84793; Puthanveettil et al., PNAS (2013), 110(18):7464-9; and Puthanveettil et al., Cell (2008), 135(5):960-73.



Position Requirements: Preferred candidates should have a Ph.D. and be able to work interactively in a highly collaborative and interactive research environment. Experience with electrophysiology (intracellular and extracellular recording) is required.

Competitive candidates will have one or more first-author manuscripts accepted in internationally recognized, peer-reviewed journals.

There will be ample opportunities available for developing new skills, interacting with other departments at Scripps Florida and with our neighboring institutions, the Max Planck Florida Institute and Florida Atlantic University. Within Scripps Florida, the Puthanveettil Laboratory collaborates extensively with both the Department of Metabolism and Aging and the Department of Molecular Therapeutics. The Scripps Florida Department of Neuroscience has state of the art facilities for imaging, behavior, genomics and biochemistry. The infrastructure at Scripps Florida includes unique chemical, genomic, proteomic, informatics, and high-throughput screening tools for the discovery of novel biomolecules.

Interested applicants should submit a Curriculum Vitae, a brief description of prior research experience, scientific interests, and contact information for three references as a single PDF file to sputhanv@scripps.edu.


Principal Investigator Peiqing Sun
Department: Cell and Molecular Biology
Location: La Jolla, CA
Maildrop: MB-41
Email application materials to: pqsun@scripps.edu
URL: http://www.scripps.edu/sun/
Research Description:

We are currently seeking a postdoctoral fellow to work within the laboratory of Dr. Sun. The lab is focused on the dissection of the signal transduction pathways mediating tumor suppressive mechanisms, such as oncogene-induced senescence, using cell culture and animal models. The fellow will be dedicated to characterization of the signaling components related to the p38 MAPK pathway in the context of oncogene-induced senescence, and will be responsible for analyzing the consequence of alterations in these components in cell culture, mouse tumor models and cancer patients.

Position Requirements: Applicants must hold a Ph.D. or equivalent degree with relevant background, and should be highly motivated and enthusiastic about research, and be able to work effectively. Expertise in molecular and cell biology is highly desirable; those with previous experience in cell culture and murine models will be given close consideration. Please send a cover letter discussing your interests in the laboratory as well as your CV and list of 3 individuals as references to pqsun@scripps.edu.
Principal Investigator Vaughn Smider
Department: Cell and Molecular Biology
Division: 3
Location: La Jolla, CA
Maildrop: MEM-150
Email application materials to: vvsmider@scripps.edu
URL: http://intranet.scripps.edu/research/cmb/faculty.html?name=smider
Research Description:

A post-doctoral Research Associate position is available in the field of antibody biology and engineering. The candidate should have experience in basic molecular biology and biochemistry techniques, including cell culture, protein purification, polymerase chain reaction, cloning, and immunoassays. He or she should be self-motivated, have good communication skills, and dedicated to a career in research.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Candidates must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Qualified applicants should submit a CV, summary of research accomplishments and interests, and names of three references to Dr. Vaughn Smider at vvsmider@scripps.edu.
Principal Investigator Claudio Joazeiro
Department: Cell and Molecular Biology
Division: 3
Location: La Jolla, CA
Maildrop: CB-163
Email application materials to: joazeiro@scripps.edu
URL: http://www.scripps.edu/joazeiro/
Research Description:

Research in the lab investigates the function of E3 ubiquitin ligases in biology and disease (Deshaies & Joazeiro, 2009. Annu Rev Biochem. 78:399-434). The position available is to elucidate the mechanism of action of the Listerin E3 in a novel pathway of ribosome-associated protein quality control, and/or how defects in Listerin function cause neurodegeneration. We had previously reported on a new mouse model of ALS/motor neuron disease caused by mutation of Listerin/Ltn1, whose function was unknown at the time (Chu et al. 2009. PNAS 106:2097-103). Listerin is conserved in eukaryotes, so we utilized S. cerevisiae to elucidate its function and mechanism of action, and found that Listerin is associated with ribosomes and mediates quality control of aberrant nascent proteins (Bengtson & Joazeiro 2010. Nature 467:470-3). Our lab is now undertaking different approaches to continue studying Listerin, including biochemistry, yeast genetics, structural biology, mammalian tissue culture, and gene-disease association studies using ALS patient samples. We are also well positioned to uncover novel molecular mechanisms underlying neurodegeneration by applying the discoveries we make with these approaches to studies on the Listerin mutant mouse model. There are opportunities for studies along any of the above research lines, depending on the background and interests of the applicant.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: A Ph.D. in Biology or in other disciplines of relevance to the project is required. The candidate should have strong conceptual and experimental background in related areas. He/she should be proactive and productive, and have track record of successful project completion.

Interested applicants, please send a paragraph on current and future research interests, and the names and contact information of three references to joazeiro@scripps.edu.
Principal Investigator Andrew Su
Department: Integrative Structural and Computational Biology
Division: 3
Location: La Jolla, CA
Maildrop: MEM-216
Email application materials to: asu@scripps.edu
URL: http://sulab.org
Research Description:

The Su Lab is currently recruiting for a postdoctoral associate in bioinformatics software development. This position will participate in the design and development of the Gene Wiki, BioGPS, and/or GeneGames.org. All of these applications developed by our lab embrace the principles of community intelligence and crowdsourcing.

Applicants should have a Ph.D. in bioinformatics or biology, and as well as a good foundation in some form of computer programming and statistics. Past experience working with modern genomics data (next gen sequencing, microarrays, proteomics, etc.) is highly desirable.

More information about the lab's interests can be found at http://sulab.org.

Interested individuals should send their CV, a letter describing research interests, and the names/contact information of 3 references to Dr. Andrew Su at: asu@scripps.edu.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
Principal Investigator Andrew Su
Department: Integrative Structural and Computational Biology
Division: 3
Location: La Jolla, CA
Maildrop: MEM-216
Email application materials to: asu@scripps.edu
URL: http://sulab.org
Research Description:

The Su Lab is recruiting for multiple postdoctoral associates in bioinformatics and computational biology. These positions will participate in a wide variety of genomics and genetics analyses in close collaboration with world-class experimental researchers at Scripps. Example projects include N-of-1 cancer genomics, osteoarthritis, cystic fibrosis, and microbiomics.

Applicants should have a Ph.D. in bioinformatics or biology, and as well as a good foundation in some form of computer programming and statistics. Past experience working with modern genomics data (next gen sequencing, microarrays, proteomics, etc.) is highly desirable.

More information about the lab's interests can be found at http://sulab.org.

Interested individuals should send their CV, a letter describing research interests, and the names/contact information of 3 references to Dr. Andrew Su at: asu@scripps.edu.

Position Requirements: Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.
Principal Investigator Qinghai Zhang
Department: Integrative Structural and Computational Biology
Division: 3
Location: La Jolla, CA
Maildrop: CB-256
Email application materials to: qinghai@scripps.edu
URL: http://www.scripps.edu/zhang/
Research Description:

A postdoctoral position in organic or bioorganic chemistry is available in the Zhang lab in the Department of Integrative Structural and Computational Biology. The successful candidate will design, synthesize and evaluate molecules for binding and functional studies with a G-protein coupled receptor and a multidrug resistance transporter.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Ph.D with strong background in organic or bioorganic chemistry is required. Qualified candidates should be self-motivated and have good writing and communication skills. Interested applicants should send their CV and the names/contact information of three references to Dr. Qinghai Zhang: Qinghai@scripps.edu.
Principal Investigator Friedbert Weiss
Department: Molecular and Cellular Neuroscience
Division: 3
Location: La Jolla, CA
Maildrop: SP-2120
Email application materials to: bweiss@scripps.edu
URL: http://intranet.scripps.edu/research/mcn/faculty.html?name=weiss
Research Description:

An NIH T32 training grant-funded postdoctoral position is available in the lab of Dr. Friedbert Weiss at The Scripps Research Institute. Our research focuses on the neurobiological bases of drug addiction with emphasis on neuroadaptive processes that convey vulnerability to relapse. For this purpose, we employ behavioral neuroscience methodologies in combination with cutting-edge molecular biology, neuroanatomical and neurochemical approaches.

The candidate will carry out research on the treatment potential of cannabidiol (CBD) for substance abuse disorders at the pharmacological, neurocircuitry, and molecular level. This research is designed to characterize the diverse scope of addiction-relevant behavioral effects of CBD as well as the mechanism of action underlying these effects.

The Scripps Research Institute (TSRI) provides a highly stimulating and challenging environment that is at the same time highly supportive. TSRI is the world's largest, private non-profit biomedical research facility conducting basic research in immunology, molecular biology, cell biology, chemistry, neurosciences, autoimmune diseases, cardiovascular disorders, and cancer research. Our lab is part of the Molecular and Cellular Neuroscience Department, and we collaborate extensively with researchers in addiction and basic neuroscience at the local, national, and international level.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Applicants are expected to be highly motivated, have a strong work ethic, excellent communication skills, and the ability to think critically. Those with a solid background in behavioral neuroscience of addiction and/or molecular biology and with strong interest to combine these two fields in their research are preferred. Note that eligibility for the T32 training grant requires a Ph.D. (conferred by June 30, 2015) and U.S. citizenship/permanent residency (see: https://grants.nih.gov/training/faq_training.htm). No consideration will be given to applicants not meeting these requirements.
Interested applicants should submit a CV, brief summary of research accomplishments and interests, as well as names and information of three references to bweiss@scripps.edu.
Principal Investigator Jerold Chun
Department: Molecular and Cellular Neuroscience
Division: 3
Location: La Jolla, CA
Maildrop: DNC-118
Email application materials to: jchun@scripps.edu
URL: http://www.scripps.edu/chun/
Research Description:

A post-doctoral position is available for an NIH funded project to study single-cell genomics and transcriptomics of neurons. Cutting-edge techniques are being combined with analyses of human and animal brains to gain insights into cell-cell variability and mosaicism, related to the normal, developing and diseased brain.

Research Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Research Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Research Associates do not have consulting privileges.

Position Requirements: Preferred candidates should have a Ph.D. and first-author publications in molecular biology, genetics, neurobiology, or related discipline and be able to work interactively in a highly collaborative and interactive research environment. Experience with RNA-seq, DNA sequencing, qPCR, FACS, and other molecular biological techniques are desirable, as would experience with bioinformatics. Strong organizational, quantitative, and communication skills in English are mandatory. Interested applicants should submit a CV, a brief description of prior research experience, scientific interests, and contact information for three references to starling@scripps.edu or jchun@scripps.edu.